IN VITRO ANALYSIS OF AKR1D1 INTERACTIONS WITH CLOPIDOGREL: EFFECTS ON ENZYME ACTIVITY AND GENE EXPRESSION
Shutevska K1*, Kadifkova Panovska T1, Zhivikj Z1, Kapedanovska Nestorovska A2
*Corresponding Author: *Corresponding Author: Kristina Shutevska, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia, +389 2 1326032 (142), k.sutevska@ff.ukim.edu.mk
page: 69

REFERENCES

Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in pa- tients presenting without persistent ST-segment el- evation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016 Jan 14;37(3):267–315. 2. Geisler T, Schaeffeler E, Dippon J, Winter S, Buse V, Bischofs C, et al. CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation. Pharmacog- enomics. 2008 Sep;9(9):1251–9. 3. Qu J, Zhang H, Rao C, Chen S, Zhao Y, Sun H, et al. Dual Antiplatelet Therapy with Clopidogrel and Aspirin Versus Aspirin Monotherapy in Patients Un- dergoing Coronary Artery Bypass Graft Surgery. J Am Heart Assoc. 2021 Jun;10(11):e020413. 4. Tan BEX, Wong PY, Baibhav B, Thakkar S, Azhar AZ, Rao M, et al. Clopidogrel Vs Aspirin Mono- therapy Following Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis. Current Problems in Car- diology. 2023 Aug 1;48(8):101174. 5. Gurbel PA, Tantry US. Clopidogrel resistance? Thromb Res. 2007;120(3):311–21. 6. Hawken TN, Berenson AM, Klopfenstein J, Leithead CC, Brinster CJ, Sternbergh WC, et al. Clopidogrel Resistance Is Common in Patients Undergoing Vas- cular and Coronary Interventions. Journal of Vascular Surgery. 2021 Jan 1;73(1):e25–6. 7. Ma TKW, Lam YY, Tan VP, Yan BP. Variability in response to clopidogrel: how important are pharma- cogenetics and drug interactions? British Journal of Clinical Pharmacology. 2011 Oct;72(4):697. 8. Ray S. Clopidogrel resistance: The way forward. In- dian Heart Journal. 2014 Sep;66(5):530. 9. Giantini A, Timan IS, Dharma R, Sukmawan R, Setiabudy R, Alwi I, et al. The role of clopidogrel resistance-related genetic and epigenetic factors in major adverse cardiovascular events among patients with acute coronary syndrome after percutaneous coronary intervention. Frontiers in Cardiovascular Medicine. 2023 Feb 8;9:1027892. 10. Sangkuhl K, Klein TE, Altman RB. Clopidogrel pathway. Pharmacogenetics and Genomics. 2010 Jul;20(7):463. 11. Savi P, Herbert JM, Pflieger AM, Dol F, Delebassee D, Combalbert J, et al. Importance of hepatic metabolism in the antiaggregating activity of the thienopyridine clopidogrel. Biochemical Pharmacology. 1992 Aug 4;44(3):527–32. 12. Jiang XL, Samant S, Lesko LJ, Schmidt S. Clinical pharmacokinetics and pharmacodynamics of clopi- dogrel. Clin Pharmacokinet. 2015 Feb;54(2):147–66. 13. Pan Y, Chen W, Xu Y, Yi X, Han Y, Yang Q, et al. Genetic Polymorphisms and Clopidogrel Efficacy for Acute Ischemic Stroke or Transient Ischemic Attack. Circulation. 2017 Jan 3;135(1):21–33. 14. Hou X, Shi J, Sun H. Gene polymorphism of cy- tochrome P450 2C19*2 and clopidogrel resistance reflected by platelet function assays: a meta-analysis. Eur J Clin Pharmacol. 2014 Sep;70(9):1041–7. 15. Ford NF. The Metabolism of Clopidogrel: CY- P2C19 Is a Minor Pathway. J Clin Pharmacol. 2016 Dec;56(12):1474–83. 16. Zanger UM, Schwab M. Cytochrome P450 en- zymes in drug metabolism: Regulation of gene ex- pression, enzyme activities, and impact of genetic variation. Pharmacology & Therapeutics. 2013 Apr 1;138(1):103–41. 17. Barski OA, Tipparaju SM, Bhatnagar A. The aldo- keto reductase superfamily and its role in drug metabolism and detoxification. Drug Metab Rev. 2008;40(4):553–624. 18. Nikolaou N, Gathercole LL, Kirkwood L, Dunford JE, Hughes BA, Gilligan LC, et al. AKR1D1 regulates glucocorticoid availability and glucocorticoid recep- tor activation in human hepatoma cells. The Journal of Steroid Biochemistry and Molecular Biology. 2019 May 1;189:218–27. 19. Penning TM, Wangtrakuldee P, Auchus RJ. Struc- tural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes. Endocr Rev. 2019 Apr 1;40(2):447–75. 20. Chen M, Penning TM. 5β-Reduced steroids and hu- man Δ(4)-3-ketosteroid 5β-reductase (AKR1D1). Steroids. 2014 May;83:17–26. 21. Chaudhry AS, Thirumaran RK, Yasuda K, Yang X, Fan Y, Strom SC, et al. Genetic Variation in Aldo- Keto Reductase 1D1 ( AKR1D1 ) Affects the Expres- sion and Activity of Multiple Cytochrome P450s. Drug Metab Dispos. 2013 Aug;41(8):1538–47. 22. Kapedanovska-Nestorovska A, Dimovski AJ, Sterjev Z, Matevska Geskovska N, Suturkova L, Ugurov P, et al. The AKR1D1*36 (rs1872930) Allelic Variant Is Independently Associated With Clopidogrel Treat- ment Outcome. Pharmgenomics Pers Med . 2019 Oct; 12:287–95. 23. Green MR, Sambrook J. Molecular Cloning: A Labo- ratory Manual. 4th ed. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2012.. 24. Brown TA. Gene Cloning and DNA Analysis: An In- troduction. 8th ed. Hoboken (NJ): Wiley-Blackwell; 2020.. 25. Shutevska K, Nestorovska AK. Cloning, expression, and purification of recombinant AKR1D1 for thera- peutic applications. Acta Pharm. 2024 Dec 17; doi: 10.2478/acph-2025-0003. Online ahead of print. 26. Möller G, Temml V, Cala Peralta A, Gruet O, Rich- omme P, Séraphin D, et al. Analogues of Natural Chalcones as Efficient Inhibitors of AKR1C3. Me- tabolites. 2022 Feb;12(2):99. 27. Nikolaou N, Gathercole LL, Marchand L, Althari S, Dempster NJ, Green CJ, et al. AKR1D1 is a novel regulator of metabolic phenotype in human hepato- cytes and is dysregulated in non-alcoholic fatty liver disease. Metabolism. 2019 Oct;99:67–80. 28. Kędzierski J, Allard JA, Odermatt A, Smieško M. Assessment of the inhibitory potential of anabolic steroids towards human AKR1D1 by computational methods and in vitro evaluation. Toxicology Letters. 2023 Aug 1;384:1–13. 29. Laurence L. Brunton, Randa Hilal-Dandan, Bjorn Knollmann, editors. Goodman & Gilman’s The Phar- macological Basis of Therapeutics. 13th ed. New York, NY, USA: McGraw Hill Education, 2017. 30. Rižner TL, Penning TM. Role of Aldo-Keto Reduc- tase Family 1 (AKR1) Enzymes in Human Steroid Metabolism. Steroids. 2013 Nov 1;79:10.1016/j.ster- oids.2013.10.012. 31. Chen M, Drury JE, Penning TM. Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1). Steroids. 2011 Apr;76(5):484–90. 32. Chen M, Drury JE, Christianson DW, Penning TM. Conversion of Human Steroid 5β-Reductase (AKR1D1) into 3β-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H. Journal of Biologi- cal Chemistry. 2012 May 11;287(20):16609–22.



Number 27
VOL. 27 (2), 2024
Number 27
VOL. 27 (1), 2024
Number 26
Number 26 VOL. 26(2), 2023 All in one
Number 26
VOL. 26(2), 2023
Number 26
VOL. 26, 2023 Supplement
Number 26
VOL. 26(1), 2023
Number 25
VOL. 25(2), 2022
Number 25
VOL. 25 (1), 2022
Number 24
VOL. 24(2), 2021
Number 24
VOL. 24(1), 2021
Number 23
VOL. 23(2), 2020
Number 22
VOL. 22(2), 2019
Number 22
VOL. 22(1), 2019
Number 22
VOL. 22, 2019 Supplement
Number 21
VOL. 21(2), 2018
Number 21
VOL. 21 (1), 2018
Number 21
VOL. 21, 2018 Supplement
Number 20
VOL. 20 (2), 2017
Number 20
VOL. 20 (1), 2017
Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006