CREBBP IS A MAJOR PROGNOSTIC BIOMARKER FOR RELAPSE IN CHILDHOOD B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA: A NATIONAL STUDY OF UNSELECTED COHORT
Krstevska Bozhinovikj E1, Matevska-Geshkovska N1, Staninova Stojovska M1, Gjorgievska E1, Jovanovska A2, Kocheva S2*, Dimovski A1,3*
*Corresponding Author: *Corresponding Authors: Prof. Aleksandar Dimovski MD PhD. Center for Biomolecular Pharmaceutical Analyses, Faculty of Pharmacy, University Ss. Cyril and Methodius in Skopje, Mother Theresa 47, 1000 Skopje, N. Macedonia adimovski@ff.ukim.edu.mk; phone number: +38923119694 ext109; Research Center for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Academy of Sciences and Arts, Bul. Krste Misirkov 2, 1000, Skopje, N. Macedonia, a.dimovski@manu.edu.mk; phone number: +38923235411
page: 5

REFERENCES

1. Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®) - NCI. Available online: https://www.cancer. gov/types/leukemia/hp/child-all-treatment-pdq (ac- cessed on 16.10.2024). 2. SEER*Explorer Application. Available online: https://seer.cancer.gov/statistics-network/explorer/ application.html?site=92&data_type=1&graph_ type=1&compareBy=sex&chk_sex_1=1&rate_ type=2&race=1&age_range=16&advopt_ precision=1&advopt_show_ci=on&hdn_ view=0&advopt_show_apc=on&advopt_ display=2#resultsRegion0 (accessed on 16.10.2024) 3. Forero RM, Hernández M, Hernández-Rivas JM. Genetics of Acute Lymphoblastic Leukemia. In Leu- kemia. Prof. Margarita Guenova (Ed.); IntechOpen: London, UK, 2013; doi:10.5772/55504 4. Studd JB, Cornish AJ, Hoang PH, Law P, Kinnersley B, Houlston R. Cancer drivers and clonal dynamics in acute lymphoblastic leukaemia subtypes. Blood Cancer J. 2021;11(11):1-10. doi:10.1038/s41408- 021-00570-9 5. Mullighan CG. The molecular genetic makeup of acute lymphoblastic leukemia. Hematology. 2012;2012(1):389-396. doi:10.1182/asheducation. V2012.1.389.3798360 6. Hunger SP, Mullighan CG. Redefining ALL classifica- tion: toward detecting high-risk ALL and implement- ing precision medicine. Blood. 2015;125(26):3977- 3987. doi:10.1182/blood-2015-02-580043 7. Woo JS, Alberti MO, Tirado CA. Childhood B-acute lymphoblastic leukemia: a genetic update. Exp. hema- tol. oncol. 2014;3(1):16. doi:10.1186/2162-3619-3-16 8. Inaba H, Greaves M, Mullighan CG. Acute lympho- blastic leukaemia. The Lancet. 2013;381(9881):1943- 1955. doi:10.1016/S0140-6736(12)62187-4 9. Rob Pieters, Charles G. Mullighan, Stephen P. Hun- ger. Advancing Diagnostics and Therapy to Reach Universal Cure in Childhood ALL. J. Clin. Oncol. 2023;41:5579-5591. doi:10.1200/JCO.23.01286 10. Chang TC, Chen W, Qu C, et al. Genomic Determi- nants of Outcome in Acute Lymphoblastic Leukemia. J. Clin. Oncol. 2024;42(29):3491-3503. doi:10.1200/ JCO.23.02238 11. Brady SW, Roberts KG, Gu Z, et al. The genomic landscape of pediatric acute lymphoblastic leuke- mia. Nat Genet. 2022;54(9):1376-1389. doi:10.1038/ s41588-022-01159-z 12. Morscio J, Van Vlierberghe P. Chemotherapy at the wheel of ALL relapse. Blood. 2020;135(1):4-5. doi:10.1182/blood.2019003870 13. Mullighan CG, Phillips LA, Su X, et al. Genomic Anal- ysis of the Clonal Origins of Relapsed Acute Lympho- blastic Leukemia. Science. 2008;322(5906):1377- 1380. doi:10.1126/science.1164266 14. Zhang H, Wang H, Qian X, et al. Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencing. BMC Cancer. 2020;20(1):211. doi:10.1186/s12885- 020-6709-7 15. Ueno H, Yoshida K, Shiozawa Y, et al. Landscape of driver mutations and their clinical impacts in pedi- atric B-cell precursor acute lymphoblastic leukemia. Blood Adv. 2020;4(20):5165. doi:10.1182/bloodad- vances.2019001307 16. van Dongen JJM, Langerak AW, Brüggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobu- lin and T-cell receptor gene recombinations in sus- pect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003;17(12):2257-2317. doi:10.1038/sj.leu.2403202 17. Krstevska Bozhinovikj E, Matevska-Geshkovska N, Stojovska M, et al. Presence of Minimal Re- sidual Disease Determined by Next-Generation Se- quencing Is Not a Reliable Prognostic Biomarker in Children with Acute Lymphoblastic Leukemia. Leuk Lymphoma 2024 (submitted) doi:10.22541/ au.172536128.83797266/v1 18. van Dongen JJ, Macintyre EA, Gabert JA, et al. Stan- dardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of mini- mal residual disease in acute leukemia. Leukemia. 1999;13(12):1901-1928. doi:10.1038/sj.leu.2401592 19. ALL IC-BFM 2009 A randomized trial of the I-BFM- SG for the management of childhood non-B acute lymphoblastic leukemia; Available online: https:// ascopubs.org/doi/suppl/10.1200/JCO.22.01760/ suppl_file/protocol1_jco.22.01760.pdf (accessed 16.10.2024) 20. Stanulla M, Dagdan E, Zaliova M, et al. IKZF1p- lus Defines a New Minimal Residual Disease–De- pendent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia. J. Clin. Oncol. 2018;36(12):1240-1249. doi:10.1200/ JCO.2017.74.3617 21. Pui CH, Mullighan CG, Evans WE, Relling MV. Pediat- ric acute lymphoblastic leukemia: where are we going and how do we get there? Blood. 2012;120(6):1165- 1174. doi:10.1182/blood-2012-05-378943 22. Li B, Brady SW, Ma X, et al. Therapy-induced muta- tions drive the genomic landscape of relapsed acute lymphoblastic leukemia. Blood. 2020;135(1):41-55. doi:10.1182/blood.2019002220 23. Oshima K, Khiabanian H, da Silva-Almeida AC, et al. Mutational landscape, clonal evolution pat- terns, and role of RAS mutations in relapsed acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2016;113(40):11306-11311. doi:10.1073/ pnas.1608420113 24. Sayyab S, Lundmark A, Larsson M, et al. Mutational patterns and clonal evolution from diagnosis to re- lapse in pediatric acute lymphoblastic leukemia. Sci Rep. 2021;11(1):15988. doi:10.1038/s41598-021- 95109-0 25. Malinowska-Ozdowy K, Frech C, Schönegger A, et al. KRAS and CREBBP mutations: a relapse- linked malicious liaison in childhood high hyper- diploid acute lymphoblastic leukemia. Leukemia. 2015;29(8):1656-1667. doi:10.1038/leu.2015.107 26. Zhu Y, Wang Z, Li Y, et al. The Role of CREBBP/ EP300 and Its Therapeutic Implications in Hema- tological Malignancies. Cancers. 2023;15(4):1219. doi:10.3390/cancers15041219 27. Ramírez-Komo JA, Delaney MA, Straign D, et al. Spontaneous loss of B lineage transcription factors leads to pre-B leukemia in Ebf1+/–Bcl-xLTg mice. Oncogenesis. 2017;6(7):e355-e355. doi:10.1038/ oncsis.2017.55 28. Yang JJ, Bhojwani D, Yang W, et al. Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lympho- blastic leukemia. Blood. 2008;112(10):4178-4183. doi:10.1182/blood-2008-06-165027 29. Li X, Lin S, Liao N, et al. The RAS-signaling- pathway-mutation-related prognosis in B-cell acute lymphoblastic leukemia: A report from South China children’s leukemia group. Hematol. Oncol. 2024;42(3):e3265. doi:10.1002/hon.3265 30. Park KJ, Kim IS. Clinically actionable mutations identified in Korean patients with high-risk acute lym- phoblastic leukemia. Ann Oncol. 2018;29:viii370- viii371. doi:10.1093/annonc/mdy286.036 31. Vervoort BMT, Butler M, Grünewald KJT, et al. IKZF1 gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia. Haematologica. Published online June 6, 2024. doi:10.3324/haematol.2023.284357 32. Stanulla M, Cavé H, Moorman AV. IKZF1 deletions in pediatric acute lymphoblastic leukemia: still a poor prognostic marker? Blood. 2020;135(4):252-260. doi:10.1182/blood.2019000813 33. Feng J, Guo Y, Yang W, et al. Childhood Acute B- Lineage Lymphoblastic Leukemia With CDKN2A/B Deletion Is a Distinct Entity With Adverse Genetic Features and Poor Clinical Outcomes. Front Oncol. 2022;12. doi:10.3389/fonc.2022.878098 34. Ampatzidou M, Papadhimitriou SI, Paisiou A, et al. The Prognostic Effect of CDKN2A/2B Gene Dele- tions in Pediatric Acute Lymphoblastic Leukemia (ALL): Independent Prognostic Significance in BFM- Based Protocols. Diagnostics. 2023;13(9):1589. doi:10.3390/diagnostics13091589 35. Oshima K, Zhao J, Pérez-Durán P, et al. Mutational and functional genetics mapping of chemotherapy resistance mechanisms in relapsed acute lympho- blastic leukemia. Nat Cancer. 2020;1(11):1113-1127. doi:10.1038/s43018-020-00124-1



Number 27
VOL. 27 (2), 2024
Number 27
VOL. 27 (1), 2024
Number 26
Number 26 VOL. 26(2), 2023 All in one
Number 26
VOL. 26(2), 2023
Number 26
VOL. 26, 2023 Supplement
Number 26
VOL. 26(1), 2023
Number 25
VOL. 25(2), 2022
Number 25
VOL. 25 (1), 2022
Number 24
VOL. 24(2), 2021
Number 24
VOL. 24(1), 2021
Number 23
VOL. 23(2), 2020
Number 22
VOL. 22(2), 2019
Number 22
VOL. 22(1), 2019
Number 22
VOL. 22, 2019 Supplement
Number 21
VOL. 21(2), 2018
Number 21
VOL. 21 (1), 2018
Number 21
VOL. 21, 2018 Supplement
Number 20
VOL. 20 (2), 2017
Number 20
VOL. 20 (1), 2017
Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006