CREBBP IS A MAJOR PROGNOSTIC BIOMARKER FOR RELAPSE IN CHILDHOOD B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA: A NATIONAL STUDY OF UNSELECTED COHORT
Krstevska Bozhinovikj E1, Matevska-Geshkovska N1, Staninova Stojovska M1,
Gjorgievska E1, Jovanovska A2, Kocheva S2*, Dimovski A1,3*
*Corresponding Author: *Corresponding Authors: Prof. Aleksandar Dimovski MD PhD. Center for Biomolecular Pharmaceutical
Analyses, Faculty of Pharmacy, University Ss. Cyril and Methodius in Skopje, Mother Theresa 47, 1000
Skopje, N. Macedonia adimovski@ff.ukim.edu.mk; phone number: +38923119694 ext109;
Research Center for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Academy
of Sciences and Arts, Bul. Krste Misirkov 2, 1000, Skopje, N. Macedonia, a.dimovski@manu.edu.mk;
phone number: +38923235411
page: 5
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ACKNOWLEDGMENTS
The authors are in debt to the patients and their fami-
lies for consenting to participate in this study. The authors
are also grateful for the thoughtful comments from Prof.
Milenko Tanasijevic and Prof. Dimitar Efremov. This re-
search was funded, in part, by the intramural funds for
science of the Center for Biomolecular Pharmaceutical
Analyses, Faculty of Pharmacy, University Ss. Cyril and
Methodius in Skopje, and the Research Center for Genetic
Engineering “Georgi D. Efremov”, Macedonian Academy
of Sciences and Arts.
Author Contributions
Conceptualization, A.D., S.K. and N.M.G.; Method-
ology, E.K.B., M.S.S. and E.G.; Software, E.K.B; Formal
Analysis, E.K.B., M.S.S and E.G; Investigation, A.D.,
S.K., N.M.G. and E.K.B.; Resources, S.K. and A.J.; Writ-
ing – Original Draft Preparation, E.K.B.; Writing – Review
& Editing, A.D., S.K. and N.M.G.; Supervision, A.D.,
S.K. and N.M.G.
Conflicts of Interest
The authors declare no conflict of interest.
Funding
This research received no external funding.
Institutional Review Board Statement
The study was conducted according to the guidelines
of the Declaration of Helsinki and approved by the Ethics
Subcommittee of the Macedonian Academy of Sciences
and Arts (date of approval 03.04.2023).
Informed Consent Statement
Informed consent was obtained from all subjects in-
volved in the study.
Data Availability Statement
The original contributions presented in the study are
included in the article/supplementary material, further
inquiries can be directed to the corresponding author/s.
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