Balkan Journal of Medical Genetics

DO GENE POLYMORPHISMS PLAY A ROLE IN NEWBORN HYPERBILIRUBINEMIA?
Hakan N, Aydin M, Ceylaner S, Di̇lli̇ D, Zenci̇roğlu A, Okumuş N
*Corresponding Author: Assoc. Prof. Nilay Hakan, MD, Division of Neonatology, Sitki Koçman University School of Medicine, Orhaniye Mah., Haluk Ozsoy Sk., 48000, Muğla / Türkiye, Phone: +90 (252) 214 13 26, Fax: +90 (252) 211 13 45, E-mail: nhakan@hotmail.com
page: 51

RESULTS

Demographic characteristics of the three groups are shown in Table 1. There was no difference between the groups in terms of mean gestational age and birth weight. There was no difference between the groups in terms of feeding patterns, gender and mode of delivery. There is a significant difference between the groups in terms of bilirubin levels. The genotype distributions on the basis of nucleotides in these three groups are shown in Table 2. There was no significant difference in genotype distribution between the case and control groups (P>0.05 in all comparisons). There were no statistically significant differences in the preva- lence of the variant of UGT1A1 gene at nt 211, variants of SLCO1B1 gene at nt 388, 463, 521 and 1463 variants of SLCO1B3 gene at nt 334, 727+118, 1865+19721 variants of GSTP1 gene at nt 313 and nt 341, and allele frequency of these genes (except SLCO1B3 at nt 334) among the three groups (P>0.05 in all comparisons, Table 2). The G allele frequency of the variant of SLCO1B3 gene at nt 334 of the infants in the idiopathic hyperbilirubinemia group was 85%, which was significantly lower than that in the control group (96%, P=0.03; Table 2). There was no statistically significant difference in the frequency of the G allele of the SLCO1B3 variant at nt 334 between infants in the prolonged jaundice and control groups (P=0.16). No variant of the SLCO1B1 gene was found at nt 1463 (rs59502379). Clinical features among genotypes based on nucleotides There was no significant difference in the mean peak bilirubin levels and the onset time of hyperbilirubinemia among the newborn infants with the different genotypes based on the UGT1A1 gene at nt 211, variants of SLCO1B1 gene at nt 388, 463, 521 and 1463, variants of SLCO1B3 gene at nt 334, 727+118 and 1865+19721, variant GSTP1 gene at nt 313 and 341 in the idiopathic hyperbilirubinemia group (Table 3). Since all newborn babies with hyperbili- rubinemia were given phototherapy, no conclusion could be reached about the duration of hyperbilirubinemia in this study (Table 3).

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