DO GENE POLYMORPHISMS PLAY A ROLE IN NEWBORN HYPERBILIRUBINEMIA?
Hakan N, Aydin M, Ceylaner S, Di̇lli̇ D, Zenci̇roğlu A, Okumuş N
*Corresponding Author: Assoc. Prof. Nilay Hakan, MD, Division of Neonatology, Sitki Koçman University School of Medicine, Orhaniye Mah., Haluk Ozsoy Sk., 48000, Muğla / Türkiye, Phone: +90 (252) 214 13 26, Fax: +90 (252) 211 13 45, E-mail: nhakan@hotmail.com
page: 51
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Abstract
Objectives
Polymorphisms of the uridine-diphospho-glucurono-
syltransferase 1A1 (UGT1A1) gene, hepatic solute carrier
organic anion transporter 1B1/B3 (SLCO1B1/3) gene, and
glutathione S-transferase (GST) gene have been associated
with significant hyperbilirubinemia in some populations.
This study aims to determine whether the variation of
UGT1A1, SLCO1B1/3 and GST genes play an important
role in neonatal hyperbilirubinemia in Turkish newborn
infants.
Methods
The study included 61 idiopathic hyperbilirubine-
mia cases, 28 prolonged jaundice cases, and 41 controls.
Ten common polymorphisms in four genes involved in
bilirubin metabolism were examined. Polymerase chain
reaction-restriction fragment length polymorphism method
was used to detect variants of those genes.
Results
No association was found between the variants of
UGT1A1 at nt 211, the SLCO1B1 gene at nt 388, 463, 521,
1463, the SLCO1B3 gene at nt 334, 727+118, 1865+19721,
and the GST gene at nt 313, 341, and neonatal hyperbili-
rubinemia. There was no difference between the case and
control groups in terms of allele frequencies of these genes
(except SLCO1B3 at nt 334) (p>0.05 in all comparisons).
The presence of the G allele of the SLCO1B3 at nt 334
variant gene seemed to protect from jaundice in infants
with idiopathic hyperbilirubinemia.
Conclusion
These gene polymorphisms currently studied do not
seem to modulate the risk of hyperbilirubinemia in Turk-
ish newborn infants.
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