CO-EXISTENCE OF CYP2C19*1/*2 AND ABCB1C.3435 CT GENOTYPE HAS A POTENTIAL IMPACT ON CLINICAL OUTCOME IN CAD PATIENTS TREATED WITH CLOPIDOGREL
Nestorovska KA, Naumovska Z, Staninova Stojovska M, Sterjev Z, Dimovski A, Suturkova Lj
*Corresponding Author: Aleksandra Kapedanovska Nestorovska, PhD, Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Skopje, RN Macedonia, Mother Theresa str 47, 1000 Skopje, R. North Macedonia, Email address: alka@ff.ukim.edu.mk
page: 35
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CONCLUSION
In summary, our results support the previous data
on the association between the presence of the CYP2C19
*2 alone, or in combination with the ABCB1 C, and the
increased risk of MACE compared to the carriers of the
wild type alleles. Namely, a higher incidence of major
adverse cardiovascular events was detected in patients
with concomitant inheritance of the CYP2C19*1/*2 and
ABCB1 CT genotype and in patients with normal CY-
P2C19 genetic status and presence of the ABCB1 3435C
allele. The results also indicate that the presence of ABCB1
C343T polymorphism might be potentially considered as
an independent predictor of adverse cardiovascular events in patients treated with clopidogrel. However, this was
an initial study conducted on a subset of the Macedonian
population, and the results should be confirmed with a
larger cohort.
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