ASSOCIATION OF 308TNF AND +252LTA SINGLE NUCLEOTIDE POLYMORPHISMS WITH HEMATOLOGICAL MALIGNANCIES IN CHILDREN FROM THE BASHKORTOSTAN REPUBLIC
Yakupova EV 1,* Krasavtceva TN2, Malyevsky OA2, Viktorova TV1
*Corresponding Author: Dr. Elvira V. Yakupova, Institute of Biochemistry and Genetics, Ufa Research Centre, Russian Academy of Science, Prospect Oktyabrya 69, Ufa 450054, Russia; Tel./Fax: +007-3472-356088; E-mail: ecolab_203@mail.ru
page: 9

INTRODUCTION

Hematological malignancies (HM) are the most common form of cancer in childhood. The incidence of AL in children is 3,7 per 100 000 in Bashkortostan Republic. Nowadays, then pediatric oncologists have become more successful at treating HM, cured rate in the developed countries nearly 80%, much of clinical research efforts have focused on stratifying patients into various risk groups based on known prognostic features (1). The prognostic factors now mostly include clinical and biological characteristics that are accessible at diagnosis. For example, the immunophenotype of the blasts is a highly significant prognostic aspect.  Advances in genetics have led to the discovery of new prognostic marks.

Tumor necrosis factor α (TNF) and Lymphotoxin α (LTA) are cytokines with pleotropic biological activities, which play an important role in the development and function of normal lymphoid tissue (2). It has also been shown that patients with malignant lymphomas have high circulating levels of TNF are associated with poor disease outcome (3). Several studies showed that excessive TNF production may influence the host status, including weight loss, cachexia, modification of the immune response, and anemia, therefore hampering the patient ability to tolerate his tumor and his treatment (4). Other experimental dates indicate that TNF may promote the growth certain lymphoid cells (5). Genes encode of these cytokines are located on chromosome 6p21, within a 7-kb DNA locus in the class III region of the major histocompatibility complex (6). In the promoter region of TNF gene has been described polymorphism -308G?A, which results in higher level of TNF expression (7). A polymorphic site +252A?G within the first intron of LTA gene also results in significantly higher LTA production (8).

The aim of this work was to test the -308TNF and +252LTA gene polymorphisms for association with HM in children from Bashkortostan Republic.

 




Number 26
VOL. 26(1), 2023
Number 25
VOL. 25(2), 2022
Number 25
VOL. 25 (1), 2022
Number 24
VOL. 24(2), 2021
Number 24
VOL. 24(1), 2021
Number 23
VOL. 23(2), 2020
Number 22
VOL. 22(2), 2019
Number 22
VOL. 22(1), 2019
Number 22
VOL. 22, 2019 Supplement
Number 21
VOL. 21(2), 2018
Number 21
VOL. 21 (1), 2018
Number 21
VOL. 21, 2018 Supplement
Number 20
VOL. 20 (2), 2017
Number 20
VOL. 20 (1), 2017
Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006