APOE4 STATUS AND COGNITIVE FUNCTION
IN MIDDLE-AGED AND ELDERLY PEOPLE
Pavel N.A.1, Paun M.R.2, Matei P.V.1,2, Dutu I.1, Tudose C.1,2
*Corresponding Author: Valentin P. Matei, Associate Proffesor, MD, PhD. 2nd Ward of “Prof. Dr. Alexandru
Obregia” Hospital, Berceni Street no 10, Bucharest, Romania. E-mail: valipmatei@yahoo.com
page: 6
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RESULTS
There were 51 patients included in the study, 11
ApoE4 positive (21.6%) and 40 controls (78.4%). There
were more female patients in each group (63.6% female
and 36.4% male in the ApoE4 positive group and 85% female
and 15% male in the control group), and the mean age
for the ApoE4 group was 65.64 years compared to 64.75
in the control group. There were no statistically significant
differences between the groups regarding locative status,
relationship status, BMI, hypertension, type II diabetes,
current treatment use, history of psychiatric disorders,
HAM-D and HAM-A scores. The fully described results
of the socio-demographic and clinical characteristics of
participants with ApoE4 compared to controls are presented
in Table 1.
There were no statistically significant differences regarding
cognitive functioning between the ApoE4 positive
group and controls, except in the Rey Complex Figure Test
- Memory (p=.019). The ApoE4 positive group exhibited
a trend of poorer performance than the control group in
most tasks. The full results of the cognitive evaluations
are presented in Table 2.
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