APOE4 STATUS AND COGNITIVE FUNCTION IN MIDDLE-AGED AND ELDERLY PEOPLE
Pavel N.A.1, Paun M.R.2, Matei P.V.1,2, Dutu I.1, Tudose C.1,2
*Corresponding Author: Valentin P. Matei, Associate Proffesor, MD, PhD. 2nd Ward of “Prof. Dr. Alexandru Obregia” Hospital, Berceni Street no 10, Bucharest, Romania. E-mail: valipmatei@yahoo.com
page: 6

RESULTS

There were 51 patients included in the study, 11 ApoE4 positive (21.6%) and 40 controls (78.4%). There were more female patients in each group (63.6% female and 36.4% male in the ApoE4 positive group and 85% female and 15% male in the control group), and the mean age for the ApoE4 group was 65.64 years compared to 64.75 in the control group. There were no statistically significant differences between the groups regarding locative status, relationship status, BMI, hypertension, type II diabetes, current treatment use, history of psychiatric disorders, HAM-D and HAM-A scores. The fully described results of the socio-demographic and clinical characteristics of participants with ApoE4 compared to controls are presented in Table 1. There were no statistically significant differences regarding cognitive functioning between the ApoE4 positive group and controls, except in the Rey Complex Figure Test - Memory (p=.019). The ApoE4 positive group exhibited a trend of poorer performance than the control group in most tasks. The full results of the cognitive evaluations are presented in Table 2.



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