MATRIX METALLOPROTEINASE-2 (MMP-2 ) AND-9 (MMP-9) GENE VARIANTS AND MICROVASCULAR COMPLICATIONS IN TYPE 2 DIABETES PATIENTS
Andjelic Jelic M٭ˡ, Radojkovic D², Nikolic A², Rakicevic Lj², Babic T², Jelic D³, Lalic NM⁴
*Corresponding Author: Marina Andjelic Jelic, Department of Endocrinology, Diabetes and Metabolic Diseases, Clinical Medical Centre Zvezdara, Dimitrija Tucovica 161, 11000 Belgrade, Serbia, Phone +381 64 122 2010 Fax +381 11 3088733, E mail: drmajelic@gmail.com
page: 6

RESULTS

The study population included 102 diabetic patients, 65 men and 37 women, aged 61.4 ± 7.3 years with a mean BMI 28.8±4.8kg m2. The mean duration of diabetes was 10.1±5.8 years. Most of the patients were on metformin (86.3 %), 22.5 % on oral antidiabetic drug (OAD), 13.7 % on insulin and 63.7 % on an OAD/insulin combination. The basic demographic features of patients with diabetes are shown in the Table 1. The control group included 56 patients who did not differ in basic demographic characteristics. Based on data given in table 2, the frequencies of the -1306C and -1306T alleles in the group of diabetic patients are 0.82 and 0.18, respectively. In the control group, the frequencies of these alleles are 0.71 for -1306C and 0.29 for -1306T. In the group of diabetic patients, the frequencies of -1562C and -1562T alleles are 0.84 and 0.16, respectively; in the control group their frequencies are 0.86 and 0.14, respectively. For the analyzed alleles, Hardy-Weinberg equilibrium testing was performed. The testing showed that the p value of Pearson’s Chi-Square test for MMP-2 alleles was 0.71 in the group of patients and 0.58 in the control group. For MMP-9 alleles, the p value of Pearson’s Chi-Square test was 0.48 and 0.21 in the group of diabetic patients and in the control group, respectively. The association of MMP-2 and MMP-9 alleles with diabetes and microvascular complications was investigated in a dominant model of inheritance. Genotype frequencies of the MMP-9 variant -1562C>T between the patients and control group were not significantly different, as was neither the difference in the C nor T allelic frequencies between the control group and patients with type 2 DM. The MMP-2 variant -1306C>T showed a negative correlation with type 2 diabetes (p=0.028). The presence of the -1306C allele increases the probability of developing type 2 diabetes 2.2 times, while the -1306 T allele a has protective role. In order to assess the impact of both variants on microvascular complications, the alleles’ frequencies were correlated with the presence of diabetic retinopathy, polyneuropathy, and nephropathy in patients with type 2 diabetes. The MMP-9 variant 1562C>T showed no association with any microvascular complications. The MMP-2 variant -1306T showed a negative correlation with diabetic polyneuropathy (p=0.017, Table 3). The presence of the -1306C allele increases the probability of developing diabetic polyneuropathy 3.4 times, while the -1306T allele has protective role. The MMP-2 variant 1306C>T showed no association with the presence of diabetic retinopathy or diabetic nephropathy.



Number 26
Number 26 VOL. 26(2), 2023 All in one
Number 26
VOL. 26(2), 2023
Number 26
VOL. 26, 2023 Supplement
Number 26
VOL. 26(1), 2023
Number 25
VOL. 25(2), 2022
Number 25
VOL. 25 (1), 2022
Number 24
VOL. 24(2), 2021
Number 24
VOL. 24(1), 2021
Number 23
VOL. 23(2), 2020
Number 22
VOL. 22(2), 2019
Number 22
VOL. 22(1), 2019
Number 22
VOL. 22, 2019 Supplement
Number 21
VOL. 21(2), 2018
Number 21
VOL. 21 (1), 2018
Number 21
VOL. 21, 2018 Supplement
Number 20
VOL. 20 (2), 2017
Number 20
VOL. 20 (1), 2017
Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006