MATRIX METALLOPROTEINASE-2 (MMP-2 )
AND-9 (MMP-9) GENE VARIANTS AND MICROVASCULAR
COMPLICATIONS IN TYPE 2 DIABETES PATIENTS
Andjelic Jelic M٭ˡ, Radojkovic D², Nikolic A², Rakicevic Lj², Babic T², Jelic D³, Lalic NM⁴
*Corresponding Author: Marina Andjelic Jelic, Department of Endocrinology, Diabetes and Metabolic
Diseases, Clinical Medical Centre Zvezdara, Dimitrija Tucovica 161, 11000 Belgrade, Serbia, Phone +381 64 122 2010 Fax +381 11 3088733, E mail: drmajelic@gmail.com
page: 6
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RESULTS
The study population included 102 diabetic patients,
65 men and 37 women, aged 61.4 ± 7.3 years with a mean
BMI 28.8±4.8kg m2. The mean duration of diabetes was
10.1±5.8 years. Most of the patients were on metformin
(86.3 %), 22.5 % on oral antidiabetic drug (OAD), 13.7 %
on insulin and 63.7 % on an OAD/insulin combination. The
basic demographic features of patients with diabetes are
shown in the Table 1. The control group included 56 patients
who did not differ in basic demographic characteristics.
Based on data given in table 2, the frequencies of
the -1306C and -1306T alleles in the group of diabetic
patients are 0.82 and 0.18, respectively. In the control
group, the frequencies of these alleles are 0.71 for -1306C
and 0.29 for -1306T. In the group of diabetic patients, the
frequencies of -1562C and -1562T alleles are 0.84 and
0.16, respectively; in the control group their frequencies
are 0.86 and 0.14, respectively.
For the analyzed alleles, Hardy-Weinberg equilibrium
testing was performed. The testing showed that the p value
of Pearson’s Chi-Square test for MMP-2 alleles was 0.71
in the group of patients and 0.58 in the control group. For
MMP-9 alleles, the p value of Pearson’s Chi-Square test
was 0.48 and 0.21 in the group of diabetic patients and in
the control group, respectively.
The association of MMP-2 and MMP-9 alleles with
diabetes and microvascular complications was investigated
in a dominant model of inheritance.
Genotype frequencies of the MMP-9 variant
-1562C>T between the patients and control group were
not significantly different, as was neither the difference in
the C nor T allelic frequencies between the control group
and patients with type 2 DM.
The MMP-2 variant -1306C>T showed a negative
correlation with type 2 diabetes (p=0.028). The presence
of the -1306C allele increases the probability of developing
type 2 diabetes 2.2 times, while the -1306 T allele a
has protective role.
In order to assess the impact of both variants on microvascular
complications, the alleles’ frequencies were
correlated with the presence of diabetic retinopathy, polyneuropathy,
and nephropathy in patients with type 2 diabetes.
The MMP-9 variant 1562C>T showed no association
with any microvascular complications. The MMP-2 variant
-1306T showed a negative correlation with diabetic
polyneuropathy (p=0.017, Table 3). The presence of the
-1306C allele increases the probability of developing diabetic
polyneuropathy 3.4 times, while the -1306T allele
has protective role.
The MMP-2 variant 1306C>T showed no association
with the presence of diabetic retinopathy or diabetic
nephropathy.
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