MATRIX METALLOPROTEINASE-2 (MMP-2 )
AND-9 (MMP-9) GENE VARIANTS AND MICROVASCULAR
COMPLICATIONS IN TYPE 2 DIABETES PATIENTS
Andjelic Jelic M٭ˡ, Radojkovic D², Nikolic A², Rakicevic Lj², Babic T², Jelic D³, Lalic NM⁴
*Corresponding Author: Marina Andjelic Jelic, Department of Endocrinology, Diabetes and Metabolic
Diseases, Clinical Medical Centre Zvezdara, Dimitrija Tucovica 161, 11000 Belgrade, Serbia, Phone +381 64 122 2010 Fax +381 11 3088733, E mail: drmajelic@gmail.com
page: 6
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STATISTICAL METHODS
Statistical analysis was performed using Statistical
Package for Social Sciences 20.0 (SPSS Inc., Chicago,
Illinois, USA). Descriptive statistics were computed as
mean values and standard deviations for continuous variables,
and as absolute frequencies and percentage values
for categorical variables.
The association between the MMP-2 (-1306 C>T)
and MMP-9 (-1562 C>T) variants with disease incidence
was examined according to the dominant genetic model
(carriers of wild type genotype vs. heterozygous and homozygous
carriers), using Pearson’s chi-squared test (χ2).
The measure of the strength of the association between
genotypes and disease incidence was expressed as an Odds
Ratio with a confidence interval of 95% CI (Confidence
Interval). A p-value less than 0.05 was considered statistically
significant.
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