MATRIX METALLOPROTEINASE-2 (MMP-2 ) AND-9 (MMP-9) GENE VARIANTS AND MICROVASCULAR COMPLICATIONS IN TYPE 2 DIABETES PATIENTS
Andjelic Jelic M٭ˡ, Radojkovic D², Nikolic A², Rakicevic Lj², Babic T², Jelic D³, Lalic NM⁴
*Corresponding Author: Marina Andjelic Jelic, Department of Endocrinology, Diabetes and Metabolic Diseases, Clinical Medical Centre Zvezdara, Dimitrija Tucovica 161, 11000 Belgrade, Serbia, Phone +381 64 122 2010 Fax +381 11 3088733, E mail: drmajelic@gmail.com
page: 6

STATISTICAL METHODS

Statistical analysis was performed using Statistical Package for Social Sciences 20.0 (SPSS Inc., Chicago, Illinois, USA). Descriptive statistics were computed as mean values and standard deviations for continuous variables, and as absolute frequencies and percentage values for categorical variables. The association between the MMP-2 (-1306 C>T) and MMP-9 (-1562 C>T) variants with disease incidence was examined according to the dominant genetic model (carriers of wild type genotype vs. heterozygous and homozygous carriers), using Pearsonís chi-squared test (χ2). The measure of the strength of the association between genotypes and disease incidence was expressed as an Odds Ratio with a confidence interval of 95% CI (Confidence Interval). A p-value less than 0.05 was considered statistically significant.



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