Balkan Journal of Medical Genetics

ASSOCIATION OF RELATIVE TELOMERE LENGTH AND RISK OF HIGH HUMAN PAPILLOMAVIRUS LOAD IN CERVICAL EPITHELIAL CELLS
Albosale A H, Mashkina E V
*Corresponding Author: Dr. Abbas Hadi Albosale, Genetics Department, Southern Federal University, 344090, Stachki, 194/1, Rostov-on-Don Province, Russia. E-mail: abbashammadi4@gmail.com
page: 65

RESULTS

The average age of the 50 participants in the HPVpositive group was 38.4 ±5.3 years, whereas the average age of the 50 HPV-negative participants was 42.8 ±6.6 years. The maximum HPV DNA loads among the 50 HPV-infected women were 8.5 log, the middle HPV DNA loads were 5.4 log, and the lowest loads were 4.1 log of HPV genomes per 105 human cells. The molecular analysis revealed that 8 participants in the case group (16% of the case group) had HPV co-infections. That is, these participants had two or more types of high-risk HPV. The most common type of mono-infection (44%) was HPV 16. HPV 18 accounted for 10% of the cases, as did HPV 33, whilst the HPV 31 type represented 8% of the cases. In addition, other HR-HPV genotypes, such as HPV 51, 56, 59, 45, and 39 were estimated to be present in 2-4% of cases (Figure 1). Comparatively longer telomeric DNA length (T/S ratios) was identified in participants in the cervical scrapings taken from the control group when a comparison was made with those from the HPV group (T/S ratios=1571.21 versus 1144.06 respectively). This is shown in (Table 2). Neither the risk HPV group (r=0.1976, p=0.1690) nor the control group (r= -0.1822, p=0.2052) revealed any significant correlation between age and telomere length (T/S ratio). However, a significant correlation was evident between HPV load and T/S ratio (r=0.4967, p=0.0002). The participants with HPV loads were subdivided into two groups to facilitate the evaluation of the extent to which the telomeric DNA length varied according to the viral load. The two groups were comprised of one group whose participants presented with an HPV load of 4-5lg and another group in which participants had HPV loads that exceeded 5lg. The analysis indicated that for participants with HPV loads of 4-5lg, the average telomere length in cervical epithelial cells (T/S ratios =1035.12) was less than that of the sample cells of participants in the HPV load (> 5lg) group (T/S=1222.93), as can be seen in Table 2) (Figure 2). Despite this finding, it should be noted that the difference between the HPV load groups (4-5lg) and (> 5lg) was not statistically significant (p= 0.118).

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