ASSOCIATION OF RELATIVE TELOMERE LENGTH
AND RISK OF HIGH HUMAN PAPILLOMAVIRUS LOAD
IN CERVICAL EPITHELIAL CELLS
Albosale A H, Mashkina E V
*Corresponding Author: Dr. Abbas Hadi Albosale, Genetics Department, Southern Federal University,
344090, Stachki, 194/1, Rostov-on-Don Province, Russia. E-mail: abbashammadi4@gmail.com
page: 65
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Abstract
Importunate high-risk HPV (HR-HPV) infection is
the most common trigger for the cervical carcinogenesis
process. In this respect, the presence of cancer can be
imputed to telomere lengthening or shortening. This paper
explores the possible correlation between relative telomere
length and viral load in two groups of women, namely:
those with high-risk HPV infection and those who do not
have this infection. Thus, samples comprising of 50 women
in each group were evaluated for this research. The Amplisens
HPV HCR screen-titre-FRT PCR kite was employed
for quantitative analysis. Relative telomere length was
quantified by real-time PCR. In each of the two HPV load
groups, there was no correlation between age and telomere
length. Telomere shortening was found in the cervical cell
samples of women with high HPV loads, compared with
women in the control group. Telomere shortening is associated
with elevated HPV loads.
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