TARGETED microRNA PROFILING IN GASTRIC CANCER
WITH CLINICAL ASSESSEMENT
Pehlevan Ozel H, Dinç T, Tiryaki RS2, Keşkus AG, Konu O, Kayilioglu SI, Coşkun F
*Corresponding Author: Tolga Dinç, M.D., Associate Professor, Department of General Surgery,
Health Sciences University, Ankara City Hospital, Üniversiteler Mahallesi 1604. Cadde No: 9 Çankaya/
Ankara/Turkey. Tel./Fax: +90-312-552-60-00. Intercom: 121514. Mobile: +90-532-481-22-75. Email:
tolga_dr@hotmail.com
page: 55
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INTRODUCTION
Gastric cancer ranks fifth among the most common
cancers and is the third top ranking factor in causing
deaths related to cancer worldwide [1]. Patients with gastric
cancer exhibit low life expectancy due to diagnosis at
an advanced stage because of absence of specific clinical
symptoms and late presentation of patients to the hospital.
Over the years, treatments specific to gastric cancer have
been designed using different classifications, which, more
recently, have become based on the molecular properties
of tumors [2,3].
Research has demonstrated that microRNAs (miRNAs)
are associated with various diseases because of their
oncogenic or tumor suppressor properties. microRNAs
play a role in cancer formation and progression because
of their involvement in angiogenesis, proliferation, invasion,
cell cycle, and differentiation [4,5]. According to the
“database of differentially expressed miRNAs in Human
Cancers (dbDEMC),” as of June 2021, there are 3268
miRNAs identified for 40 different cancer types, of which
2584 are differentially expressed miRNAs seen in humans
[6]. Gastric cancer ranks high among cancer types whose
miRNAs have been identified, such as prostate cancer,
breast cancer, esophageal cancer, lung cancer. Accordingly,
1621 upreg-ulated, 1725 downregulated (and some
of which can be both downregulated and upregulated)
miRNAs have been found to be associated with gastric cancer; and were significant in terms of diagnosis, prognosis,
and treatment processes in studies conducted on
tissue or bodily fluids [6].
The purpose of the present study was to determine
the expression levels of a selected set of miRNAs in an
independent cohort of adult patients aged >18 years, who
were diagnosed with gastric adenocarcinoma with strict
selection criteria. Accordingly, we have identified, via realtime
quantitative polymerase chain reaction (qRT-PCR),
the miRNA expression and then compared the clinicopathological
characteristics of these miRNA markers that
could potentially be used in early diagnosis and innovative
treatments of gastric cancers.
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