
MUTATION STATUS AND IMMUNOHISTOCHEMICAL
CORRELATION OF EGFR MUTATIONS IN
GASTROINTESTINAL STROMAL TUMORS Ozkayalar H1, Ergoren MC2,3,*, Tuncel G2,3, Kurt S4, Cevik E4, Ozemri Sag S4,
Yilmaz Ozguven B5, Kabukcuoglu F5, Mocan G1,2, Temel ŞG4,6,7,* *Corresponding Author: Associate Professor Mahmut C. Ergoren, Department of Medical Genetics,
Faculty of Medicine, Near East University, Near East Boulevard, 99138 Nicosia, Northern Cyprus.
Tel.: +90-392-444-0535. Fax: +90-392-223-6461. E-mail: mahmucerkez.ergoren@neu.edu.tr. And/or:
Associate Professor Sehime G. Temel, Department of Medical Genetics, Faculty of Medicine, Bursa
Uludag University, Özlüce Görüjke Kampüsü, 16059 Nilüfer, Bursa, Turkey. Tel.: +90-224-295-0000.
Fax: +90-224-295-0019. E-mail: sehime@uludag.edu.tr. page: 67
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REFERENCES
1. Miettinen M, Lasota J. Gastrointestinal stromal
tumors: Pathology and prognosis at different sites.
Semin Diagn Pathol. 2006; 23(2): 70-83.
2. DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff
JM, Brennan MF. Two hundred gastrointestinal stromal
tumors: Recurrence patterns and prognostic factors
for survival. Ann Surg. 2000; 231(1): 51-58.
3. Lv M, Wu C, Zheng Y, Zhao N. Incidence and survival
analysis of gastrointestinal stromal tumors in
Shanghai: A population-based study from 2001 to
2010. Gastroenterol Res Pract. 2014; 2014: 83416
4. Pisani P, Parkin DM, Bray F, Ferlay J. Estimates of
the worldwide mortality from 25 cancers in 1990. Int
J Cancer. 1999; 83(1): 18-29.
5. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers
C, Rebelo M, et al. Cancer incidence and mortality
worldwide: sources, methods and major patterns
in GLOBOCAN 2012. Int J Cancer. 2015; 136(5):
E359-E386.
6. Zhao X, Yue C. Gastrointestinal stromal tumor. J
Gastrointest Oncol. 2012; 3(3): 189-208. 7. ESMO/European Sarcoma Network Working Group.
Gastrointestinal stromal tumors: ESMO Clinical
Practice Guidelines for diagnosis, treatment and follow-
up. Ann Oncol. 2012; 23(Suppl 7): vii49-vii55.
8. Lux ML, Rubin BP, Biase TL, Chen CJ, Maclure T,
Demerti G, et al. KIT extracellular and kinase domain
mutations in gastrointestinal stromal tumors. Am J
Pathol. 2000; 156(3): 791-795.
9. Heinrich MC, Corless CL, Demetri GD, Blanke CD,
von Mehren M, Joensuu H, et al. Kinase mutations
and imatinib response in patients with metastatic
gastrointestinal stromal tumor. J Clin Oncol. 2003;
21(23): 4342-4349.
10. Duffy MJ, Lamerz R, Haglund C, Nicolini A,
Kalousová M, Holubec L, et al. Tumor markers in
colorectal cancer, gastric cancer and gastrointestinal
stromal cancers: European group on tumor markers
2014 guidelines update. Int J Cancer. 2014; 134(11):
2513-2522.
11. Heinrich MC, Corless CL, Duensing A, McGreevey
L, Chen C-J, Joseph N, et al. PDGFRA activating
mutations in gastrointestinal stromal tumors. Science.
2003; 299(5607): 708-710.
12. Moutinho C, Mateus AR, Milanezi F, Carneiro F,
Seruca R, Suriano G. Epidermal growth factor receptor
structural alterations in gastric cancer. BMC
Cancer. 2008; 8(10): 10.
13. Cohen RB. Epidermal growth factor receptor as a
therapeutic target in colorectal cancer. Clin Colorectal
Cancer. 2003; 2(4): 246-251.
14. Yarden Y. The EGFR family and its ligands in human
cancer. Signalling mechanisms and therapeutic opportunities.
Eur J Cancer. 2001; 37(Suppl 4): S3-S8.
15. Voldborg BR, Damstrup L, Spang-Thomsen M,
Poulsen HS. Epidermal growth factor receptor (EGFR)
and EGFR mutations, function and possible role in
clinical trials. Ann Oncol. 1997; 8(12): 1197-1206.
16. Yamaoka T, Ohba M, Ohmori T. Molecular-targeted
therapies for epidermal growth factor receptor and its resistance
mechanisms. Int J Mol Sci. 2017; 18(11): 2420.
17. Edris B, Espinosa I, Mühlenberg T, Mikels A, Lee
CH, Steigen SE, et al. ROR2 is a novel prognostic
biomarker and a potential therapeutic target in leiomyosarcoma
and gastrointestinal stromal tumour. J
Pathol. 2012; 227(2): 223-233.
18. Rubin BP, Heinrich MC, Corless CL. Gastrointestinal
stromal tumour. Lancet. 2007; 369(9574): 1731-1741.
19. Hynes NE, Lane HA. ERBB receptors and cancer:
The complexity of targeted inhibitors. Nat Rev
Cancer. 2005; 5(5): 341-354.
20. Jiang Z, Li C, Li F, Wang X. EGFR gene copy number
as a prognostic marker in colorectal cancer patients
treated with cetuximab or panitumumab: A systematic
review and meta analysis. PLoS One. 2013; 8(2):
e56205.
21. Temel S, Uren D, Yakicier MC. Genetics and molecular
basis of gastric cancer. In: Canbay E, Zilberstein B,
Sossai P, Jinjuvadia K, Catterjee I, Editors. Overview
on Gastric Cancer, 3rd ed. Las Vegas, NV, USA: Open
Access eBooks. 2018: 1-13.
22. Metro G. EGFR targeted therapy for lung cancer:
are we almost there? Transl Lung Cancer Res. 2018;
7(Suppl 2): S142-S145.
23. Ergin K, Gürsoy E, Başimoǧlu Koca Y, Başaloǧlu H,
Seyrek K. Immunohistochemical detection of insulin-
like growth factor-I, transforming growth factorbeta2,
basic fibroblast growth factor and epidermal
growth factor-receptor expression in developing rat
ovary. Cytokine. 2008; 43(2): 209-214.
24. Shi S-S, Wu N, He Y, Wei X, Xia Q-Y, Wang X, et
al. EFGR gene mutation in gastrointestinal stromal
tumors. Histopathology. 2017; 71(4): 553-561.
25. Apicella M, Corso S, Giordano S. Targeted therapies
for gastric cancer: Failures and hopes from clinical
trials. Oncotarget. 2017; 8(34): 57654-57669.
26. Cancer Genome Atlas Research Network. Comprehensive
molecular characterization of gastric adenocarcinoma.
Nature. 2014; 513(7517): 202-209.
27. Huss S, Künstlinger H, Warderlmann E, Kleine MA,
Binot E, Merkelbach-Bruse S, et al. A subset of gastrointestinal
stromal tumors previously regarded as
wild-type tumors carries somatic activating mutations
in KIT exon 8 (pD419del). Mod Pathol. 2013; 26(7):
1004-1012.
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