Balkan Journal of Medical Genetics

MUTATION STATUS AND IMMUNOHISTOCHEMICAL CORRELATION OF EGFR MUTATIONS IN GASTROINTESTINAL STROMAL TUMORS
Ozkayalar H1, Ergoren MC2,3,*, Tuncel G2,3, Kurt S4, Cevik E4, Ozemri Sag S4, Yilmaz Ozguven B5, Kabukcuoglu F5, Mocan G1,2, Temel ŞG4,6,7,*
*Corresponding Author: Associate Professor Mahmut C. Ergoren, Department of Medical Genetics, Faculty of Medicine, Near East University, Near East Boulevard, 99138 Nicosia, Northern Cyprus. Tel.: +90-392-444-0535. Fax: +90-392-223-6461. E-mail: mahmucerkez.ergoren@neu.edu.tr. And/or: Associate Professor Sehime G. Temel, Department of Medical Genetics, Faculty of Medicine, Bursa Uludag University, Özlüce Görüjke Kampüsü, 16059 Nilüfer, Bursa, Turkey. Tel.: +90-224-295-0000. Fax: +90-224-295-0019. E-mail: sehime@uludag.edu.tr.
page: 67

RESULTS

Nineteen female and 21 male patients (total 40) participated in the study with average ages 57.3 and 62.4, respectively. Minimum and maximum ages in women were 24 and 78, whereas it was 45 and 77 in men. Age and gender of the patients, location and cell types of tumors are shown in Table 1 below. At the end of the molecular genetic analysis, no mutations were detected in the most common six hot-spot regions that included codon 719 in exon 18, deletion of exon 19, codons 768 and 790 in exon 20 and codons 858 and 861 in exon 21 of the EGFR gene tested in 40 different somatic GIST patients. Probably, immunohistochemical analyses showed no expression of EGFR in the tested somatic tumor samples (Figure 1).

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