INCREASED EXPRESSION OF CARDIOTROPHIN-1
IN CARDIOMYOPATHY PATIENTS
Sharif S1,*, Saleem A1, Naz S1, Rashid F1, Iqtedar M2, Kaleem A2, Latif A1
*Corresponding Author: Dr. Saima Sharif, Department of Zoology, Lahore College for Women
University, Jail Road, Lahore, Pakistan. Tel: +92-333-409-2232. Fax: +92-042-9920-3077. E-mail:
saimasharif04@ gmail.com
page: 21
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RESULTS
The demographic characteristics are presented in Table
1. In the control group, 80.0% were males and 20.0% were
females. In the CM group, 45.0% were males and 55.0%
were females. Systolic blood pressure (SBP) and diastolic
BP (DBP) of the CM group was 124.0±0.7 and 83.0±0.8
mmHg, respectively, as compared to the control group in
which SBP was 103.0±0.9 and DBP was 79.0±1.5 mmHg,
respectively. Etiological attributes of the disease were idiopathic
65.0%, nutritional 15.0% and multifactorial 15.0%.
In the CM group, 15.0% were former smokers but in control
group no one was a smoker. Symptomatology of the disease
includes 85.0% breathlessness, palpitation 75.0% and chest
pain was observed in 40.0% of the subjects. On the basis
of physical activity, three categories were formed: vigorous
activity, moderate activity and sedentary life style. In control
group, 20.0% showed vigorous activity, 10.0% sedentary
lifestyle and 70.0% were moderately active. In DCM group,
5.0% showed vigorous activity, 20.0% showed moderate
activity and 75.0% had sedentary lifestyle (Table 2).
The expression of CT-1 in the CM group was in the
range of 3.8 to 8.6 with the mean value of 5.2±0.66, while
for the control group, gene expression level was 1.00.
Consequently, the CT-1 gene expression level was significantly
increased (p <0.05) in the CM group as compared
to the control group (Figure 1).
Pearson correlation coefficient between CT-1 and
other parameters revealed a highly significant relationship
with age and BMI (Figure 2), while non significant
correlation with SBP and DBP (Table 3). In the control
group, the value of expression is one so correlation cannot
be calculated.
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