INCREASED EXPRESSION OF CARDIOTROPHIN-1
IN CARDIOMYOPATHY PATIENTS
Sharif S1,*, Saleem A1, Naz S1, Rashid F1, Iqtedar M2, Kaleem A2, Latif A1
*Corresponding Author: Dr. Saima Sharif, Department of Zoology, Lahore College for Women
University, Jail Road, Lahore, Pakistan. Tel: +92-333-409-2232. Fax: +92-042-9920-3077. E-mail:
saimasharif04@ gmail.com
page: 21
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Abstract
Cardiomyopathy (CM) is a condition of cardiac dysfunction.
It is one of the leading causes of mortality in
which both genetic and environmental factors are involved.
Cardiotrophin-1 (CT-1) level in plasma is associated with
CM. It affects the cardiomyocyte differentiation. To evaluate
the expression of CT-1 in cardiomyopathy, this study
was done on CM subjects attending the Fatima Memorial
Hospital, Lahore, Pakistan, between January and June,
2016. A total of 40 subjects were enrolled who were divided
into two groups; CM group (n = 20) and a control
group (n = 20). A self-designed questionnaire was filled in
by each subject to collect data regarding age, body mass
index (BMI) and CM history. RNA was isolated from blood
after its quantification, cDNA was prepared and reversetranscriptase-
polymerase chain reaction (RT-PCR) was
performed for expression of CT-1. The mean age in CM
subjects was 40.1±6.03 years, while it was 35.0±3.7 years
in the control group. The mean expression of CT-1 in the
CM subjects was 5.2±0.66, while it was 1.00±0.001 in the
control group. A highly significant difference was observed
in CT-1 expression in the CM group, and expression was
significantly correlated with age and BMI in CM subjects.
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