TWIST1 GENE EXPRESSION AS A BIOMARKER FOR
PREDICTING PRIMARY DOXORUBICIN RESISTANCE
IN BREAST CANCER
Demir S1,10,*, Müslümanoğlu MH2, Müslümanoğlu M3, Başaran S4,
Çalay ZZ5, Aydıner A6, Vogt U7, Çakır T8, Kadıoğlu H9, Artan S1
*Corresponding Author: Selma Demir, Ph.D., Trakya University Faculty of Medicine, Department of
Medical Genetics, 22030 Iskender, Edirne, Turkey. Tel: +90(284)2357642/2330. Fax: +90(284)2357652.
E-mail: selmaulusal@trakya.edu.tr
page: 25
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RESULTS
ATP-TCA Results. Nine out of 26 tumors were found
to be resistant to doxorubicin. Histological grade, HER2,
estrogen and progesterone receptor positivity and lymph
node metastasis status of responsive and non responsive
tumors did not differ significantly. Findings and clinical
characteristics of the responsive and non responsive tumor
samples are summarized in Table 1.
TWIST1 Gene Expression Results. When tumors
were grouped according to their response to the chemotherapeutic
agent doxorubicin, there was a significant difference
for TWIST gene expression between responders
and non responders (p = 0.041) (Figure1). TWIST gene
expression of the drug-resistant group was higher than
the responsive group. This difference was not dependent
on the histopathological features of tumors because the
TWIST gene expression difference was not significantly
differed according to histological grade, hormone receptor
or lymph node positivity and HER2 (erb-b2 receptor tyrosine
kinase 2) status. The results are summarized in Table 1.
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