ASSOCIATION BETWEEN THE
CATECHOL-O-METHYLTRANSFERASE Val158Met
POLYMORPHISM WITH SUSCEPTIBILITY
AND SEVERITY OF CARPAL TUNNEL SYNDROME
Erkol İnal E1,*, Eroğlu P2, Görükmez O3, Özemri Sağ Ş4, Yakut T4
*Corresponding Author: Dr. Esra Erkol İnal, Department of Physical Medicine and Rehabilitation, Süleyman
Demirel University, Faculty of Medicine, Afyon yolu, Çünür, Isparta, Turkey. Tel: +90-246-211-9280. GSM:
+90-507-563-6511. Fax: +90-246-211-2830. E-mail: esraerkol@hotmail.com
page: 43
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RESULTS
The ages of the patients and the healthy controls
were 46.3 ± 12.0 and 46.8 ± 11.3 years, respectively
(p = 0.775). No one showed minimal CTS, 47 women
had mild CTS, 40 of the patients had moderate CTS,
and the remaining eight had severe CTS. The mean
duration of the symptoms was 31.5 ± 36.6 months,
while the mean pain level relating to the last 2 weeks
was 7.01 ± 3.4 cm on VAS.
The Val158Met genotype distributions in women
with CTS and healthy women significantly deviated
from the Hardy-Weinberg equilibrium (p <0.001 for
both). There was not a significant difference in the
distribution of the genotypes and alleles of the COMT
gene Val158Met SNP between women with CTS and
healthy women (p = 0.46) (Table 1). We also did not
find any significant difference according to genotypes
in terms of symptom duration, severity of pain and
ENG, and Boston FSS and SSS (Table 2).
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