ASSOCIATION BETWEEN THE CATECHOL-O-METHYLTRANSFERASE Val158Met POLYMORPHISM WITH SUSCEPTIBILITY AND SEVERITY OF CARPAL TUNNEL SYNDROME
Erkol İnal E1,*, Eroğlu P2, Görükmez O3, Özemri Sağ Ş4, Yakut T4
*Corresponding Author: Dr. Esra Erkol İnal, Department of Physical Medicine and Rehabilitation, Süleyman Demirel University, Faculty of Medicine, Afyon yolu, Çünür, Isparta, Turkey. Tel: +90-246-211-9280. GSM: +90-507-563-6511. Fax: +90-246-211-2830. E-mail: esraerkol@hotmail.com
page: 43

RESULTS

The ages of the patients and the healthy controls were 46.3 12.0 and 46.8 11.3 years, respectively (p = 0.775). No one showed minimal CTS, 47 women had mild CTS, 40 of the patients had moderate CTS, and the remaining eight had severe CTS. The mean duration of the symptoms was 31.5 36.6 months, while the mean pain level relating to the last 2 weeks was 7.01 3.4 cm on VAS. The Val158Met genotype distributions in women with CTS and healthy women significantly deviated from the Hardy-Weinberg equilibrium (p <0.001 for both). There was not a significant difference in the distribution of the genotypes and alleles of the COMT gene Val158Met SNP between women with CTS and healthy women (p = 0.46) (Table 1). We also did not find any significant difference according to genotypes in terms of symptom duration, severity of pain and ENG, and Boston FSS and SSS (Table 2).



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