ASSOCIATION BETWEEN THE CATECHOL-O-METHYLTRANSFERASE Val158Met POLYMORPHISM WITH SUSCEPTIBILITY AND SEVERITY OF CARPAL TUNNEL SYNDROME
Erkol İnal E1,*, Eroğlu P2, Görükmez O3, Özemri Sağ Ş4, Yakut T4
*Corresponding Author: Dr. Esra Erkol İnal, Department of Physical Medicine and Rehabilitation, Süleyman Demirel University, Faculty of Medicine, Afyon yolu, Çünür, Isparta, Turkey. Tel: +90-246-211-9280. GSM: +90-507-563-6511. Fax: +90-246-211-2830. E-mail: esraerkol@hotmail.com
page: 43

INTRODUCTION

Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper extremity [1]. Patients with CTS may have different pain sensations. [2]. There is rising interest in the genetic predisposition to the painful conditions as they may be helpful in explaining the different pain responses to the same painful stimuli [3]. Three single nucleotide polymorphisms (SNPs) were accepted to impact pain perception: catechol-O-methyltransferase (COMT) Val158Met (rs4680), brain derived neurotrophic factor Val66Met and μ-opioid receptor 1 A118G [4,5]. The COMT is an enzyme that metabolizes catecholamines such as dopamine, norepinephrine or epinephrine and has been reported to participate in the pathogenesis of several neuropsychiatric disorders [6]. The COMT gene is one of the several genes taking part in nociceptive processing; however, its role remains controversial. The COMT gene Val158Met SNP leads to a substitution of valine with methionine at codon 158 on chromosome 22q11. This substitution results in differences in the COMT enzyme activity [7]. The presence of the valine allele results in high enzymatic activity, whereas the presence of the methionine allele is linked to low enzymatic activity [8]. The Met/Met genotype was linked to increased pain sensitivity because of low enzymatic activity that leads the accumulation of catecholamines, whereas the Val/Val genotype results in reduced pain sensitivity. In only one study was the COMT gene Val158Met SNP found not to be related to CTS development but was associated with increased perception of pain and higher disability scores [9]. However, this result is not conclusive. Therefore, we aimed to determine the associations between the COMT gene Val158Met SNP and clinical and functional status of CTS.



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