GENOME-WIDE METHYLATION PROFILING
OF SCHIZOPHRENIA
Rukova B1, Staneva R1, Hadjidekova S1, Stamenov G2, Milanova V3, Toncheva D1,
*Corresponding Author: Professor Draga Toncheva, Department of Medical Genetics, Medical University of
Sofia, 1431 2 Zdrave Str., Sofia, Bulgaria. Tel./Fax: +35929520357. Email: dragatoncheva@ gmail.com
page: 15
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CONCLUSIONS
In our study, we performed genome-wide methylation
analyses, based on pool and individual samples.
As a result we proposed several new schizophrenia
candidate genes that principally participate
in synaptic transmission and nervous system development.
The most likely candidate gene is CASP3,
which is involved in apoptosis and plays a role in the
regulation of neurotransmission.
As there could be gender-specific differences,
we tested the genders separately and found the XIAP,
GABRD, OXT and KRT7 genes to be the most likely
candidates in the female group. In the male pool,
the main genes of interest were DHX37, MAP2K2,
FNDC4 and GIPC1. According to these data we extended
the hypothesis that there are differences in
the mechanism of disease development in males and
females.
Our data revealed major differences in methylation
profile between schizophrenia patients and controls
and between male and female patients. The dysregulated
activity of revealed candidate genes could
play a critical role in schizophrenia pathogenesis.
Declaration of Interest. This study was funded
by the Bulgarian National Science Fund (BNSF)
grant DMY O3/36-12.12.2011, DO02-12/10.02.2009
and DTK 02/76-21.12.2009. The authors report no
conflicts of interest. The authors alone are responsible
for the content and writing of this article.
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