GENOME-WIDE METHYLATION PROFILING
OF SCHIZOPHRENIA
Rukova B1, Staneva R1, Hadjidekova S1, Stamenov G2, Milanova V3, Toncheva D1,
*Corresponding Author: Professor Draga Toncheva, Department of Medical Genetics, Medical University of
Sofia, 1431 2 Zdrave Str., Sofia, Bulgaria. Tel./Fax: +35929520357. Email: dragatoncheva@ gmail.com
page: 15
download article in pdf format
|
|
Abstract
Schizophrenia is one of the major psychiatric
disorders. It is a disorder of complex inheritance,
involving both heritable and environmental factors.
DNA methylation is an inheritable epigenetic modification
that stably alters gene expression. We reasoned
that genetic modifications that are a result of environmental
stimuli could also make a contribution.
We have performed 26 high-resolution genomewide
methylation array analyses to determine the
methylation status of 27,627 CpG islands and compared
the data between patients and healthy controls.
Methylation profiles of DNAs were analyzed in six
pools: 220 schizophrenia patients; 220 age-matched
healthy controls; 110 female schizophrenia patients;
110 age-matched healthy females; 110 male schizophrenia
patients; 110 age-matched healthy males.
We also investigated the methylation status of 20
individual patient DNA samples (eight females and
12 males.
We found significant differences in the methylation
profile between schizophrenia and control DNA
pools. We found new candidate genes that principally
participate in apoptosis, synaptic transmission
and nervous system development (GABRA2, LIN7B,
CASP3). Methylation profiles differed between the
genders. In females, the most important genes participate
in apoptosis and synaptic transmission (XIAP,
GABRD, OXT, KRT7), whereas in the males, the
implicated genes in the molecular pathology of the
disease were DHX37, MAP2K2, FNDC4 and GIPC1.
Data from the individual methylation analyses confirmed,
the gender-specific pools results.
Our data revealed major differences in methylation
profiles between schizophrenia patients and
controls and between male and female patients. The
dysregulated activity of the candidate genes could
play a role in schizophrenia pathogenesis.
|
|
|
|
 |
Number 27
VOL. 27 (1), 2024 |
Number 26
Number 26 VOL. 26(2), 2023 All in one |
Number 26
VOL. 26(2), 2023 |
Number 26
VOL. 26, 2023 Supplement |
Number 26
VOL. 26(1), 2023 |
Number 25
VOL. 25(2), 2022 |
Number 25
VOL. 25 (1), 2022 |
Number 24
VOL. 24(2), 2021 |
Number 24
VOL. 24(1), 2021 |
Number 23
VOL. 23(2), 2020 |
Number 22
VOL. 22(2), 2019 |
Number 22
VOL. 22(1), 2019 |
Number 22
VOL. 22, 2019 Supplement |
Number 21
VOL. 21(2), 2018 |
Number 21
VOL. 21 (1), 2018 |
Number 21
VOL. 21, 2018 Supplement |
Number 20
VOL. 20 (2), 2017 |
Number 20
VOL. 20 (1), 2017 |
Number 19
VOL. 19 (2), 2016 |
Number 19
VOL. 19 (1), 2016 |
Number 18
VOL. 18 (2), 2015 |
Number 18
VOL. 18 (1), 2015 |
Number 17
VOL. 17 (2), 2014 |
Number 17
VOL. 17 (1), 2014 |
Number 16
VOL. 16 (2), 2013 |
Number 16
VOL. 16 (1), 2013 |
Number 15
VOL. 15 (2), 2012 |
Number 15
VOL. 15, 2012 Supplement |
Number 15
Vol. 15 (1), 2012 |
Number 14
14 - Vol. 14 (2), 2011 |
Number 14
The 9th Balkan Congress of Medical Genetics |
Number 14
14 - Vol. 14 (1), 2011 |
Number 13
Vol. 13 (2), 2010 |
Number 13
Vol.13 (1), 2010 |
Number 12
Vol.12 (2), 2009 |
Number 12
Vol.12 (1), 2009 |
Number 11
Vol.11 (2),2008 |
Number 11
Vol.11 (1),2008 |
Number 10
Vol.10 (2), 2007 |
Number 10
10 (1),2007 |
Number 9
1&2, 2006 |
Number 9
3&4, 2006 |
Number 8
1&2, 2005 |
Number 8
3&4, 2004 |
Number 7
1&2, 2004 |
Number 6
3&4, 2003 |
Number 6
1&2, 2003 |
Number 5
3&4, 2002 |
Number 5
1&2, 2002 |
Number 4
Vol.3 (4), 2000 |
Number 4
Vol.2 (4), 1999 |
Number 4
Vol.1 (4), 1998 |
Number 4
3&4, 2001 |
Number 4
1&2, 2001 |
Number 3
Vol.3 (3), 2000 |
Number 3
Vol.2 (3), 1999 |
Number 3
Vol.1 (3), 1998 |
Number 2
Vol.3(2), 2000 |
Number 2
Vol.1 (2), 1998 |
Number 2
Vol.2 (2), 1999 |
Number 1
Vol.3 (1), 2000 |
Number 1
Vol.2 (1), 1999 |
Number 1
Vol.1 (1), 1998 |
|
|
|
