LACK OF ASSOCIATION OF TUMOR NECROSIS FACTOR-α G–308A AND TRANSFORMING GROWTH FACTOR-β1 C–509T POLYMORPHISMS IN PATIENTS WITH DEEP NECK SPACE INFECTIONS
Jevtović-Stoimenov T1, Despotović M1,*, Pešić Z2, Ćosić A2
*Corresponding Author: Milena Despotović, M.D., Department of Biochemistry, Faculty of Medicine, University of Niš, Bulevar dr Zorana Đinđića 81, 18000 Niš, Serbia; Tel.: +381-62-606-036; Fax: +381-18-423-8770; E-mail: milena.despotovic@ymail.com
page: 59

RESULTS

Forty-one patients and 44 unrelated controls were involved in this study. The demographic characteristics of the study groups are summarized in Table 2. Genotype frequencies for the SNPs in the study groups were in Hardy-Weinberg equilibrium (p >0.05). As the TNF-a -308 AA genotype was present in only a small number of subjects (only one in the control group and two in the patients), it was analyzed together with individuals heterozygous for the TNF-a -308 polymorphism. The observed TNF-a -308 genotype distribution in the patients’ group did not show significant differences compared to C-reactive protein levels and WBC counts, as well as their relation to TNF-a G-308A and TGF-b1 C-509T genotypes were determined in patients with deep neck space infections. The CRP levels were found to be 5- to 60-fold over the base line. The obtained results show no correlation of CRP levels and WBC counts with TNF-a G-308A and TGF-b1 C-509T genotypes (Table 6). Furthermore, after the classification of the patients by diagnosis, neither CRP levels (p = 0.699) nor WBC counts (p = 0.787), showed significant difference between the groups.controls (Table 3). Moreover, no differences in the distribution of TNF -308G and TNF -308A alleles were observed between the patient and control groups (Table 4). The genotype and allele distribution of the TGF-b1 C-509T gene polymorphism did not show significant differences compared to controls (Tables 3 and 4). Also, no association of the particular genotype or allele of the TNF-a G-308A and TGF-b1 C-509T polymorphisms was obtained after the classification of the samples by diagnosis (Table 5). Furthermore, in order to evaluate the common association of polymorphic alleles, we investigated the association of the combination of high producing TNF -308A and TGF -509T alleles. The data regrouping was as follows: A+/T+ (high TNF-a/high TGF-b1), A+/T– (high TNF-a/low TGF-b1), A–/T+ (low TNF-a/high TGF-b1), A–/T– (low TNF-a/low TGF-b1). However, no statistically significant differences were observed (c2 = 1.069, df = 3, p = 0.784).



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