LACK OF ASSOCIATION OF TUMOR NECROSIS
FACTOR-α G–308A AND TRANSFORMING GROWTH
FACTOR-β1 C–509T POLYMORPHISMS IN PATIENTS
WITH DEEP NECK SPACE INFECTIONS Jevtović-Stoimenov T1, Despotović M1,*, Pešić Z2, Ćosić A2 *Corresponding Author: Milena Despotović, M.D., Department of Biochemistry, Faculty of Medicine, University
of Niš, Bulevar dr Zorana Đinđića 81, 18000 Niš, Serbia; Tel.: +381-62-606-036; Fax: +381-18-423-8770;
E-mail: milena.despotovic@ymail.com page: 59 download article in pdf format
|
Abstract
Deep neck space infections are defined as infections
that spread along the fascial planes and spaces
of the head and neck. Even in the era of antibiotics,
these infections can and have been potentially
life-threatening conditions. The role of single nucleotide
polymorphisms (SNPs) of tumor necrosis
factor-a (TNF-a) and transforming growth factor-b1
(TGF-b1) genes in deep neck infections has not been
studied. Thus, the aim of this study was to investigate
the distribution of the TNF-a G-308A and TGF-b1
C-509T polymorphisms in patients suffering from
infections of deep neck spaces and to determine the
correlation of these polymorphisms with the values
of inflammation markers [C-reactive protein (CRP)
and white blood cell (WBC) count]. A total of 41
patients with infections of deep neck spaces and 44
healthy controls were screened for TNF-a G-308A
and TGF-b1 C-509T polymorphisms using the polymerase
chain reaction-restriction fragment length
polymorphism (PCR-RFLP) method. The distribution
of the TNF-a G-308A genotype in patients did
not reveal statistically significant correlation compared
to con-trols (p = 0.483, c2 = 0.491) as well as
the distribution of the TGF-b1 C-509T genotypes
(p = 0.644, c2 = 0.725). The distribution of TNF-a
-308 and TGF-b1 -509 alleles was not significantly
different in patients compared to controls. Moreover,
CRP levels and WBC counts were not associated
with TNF-a G-308A and TGF-b1 C-509T promoter
polymorphisms in patients with deep neck infections.
In conclusion, our study suggests that the TNF-a
G-308A and TGF-b1 C-509T polymorphisms are
not associated with infections of deep neck spaces.
|
|
|
|
|
Number 26 Number 26 VOL. 26(2), 2023 All in one |
Number 26 VOL. 26(2), 2023 |
Number 26 VOL. 26, 2023 Supplement |
Number 26 VOL. 26(1), 2023 |
Number 25 VOL. 25(2), 2022 |
Number 25 VOL. 25 (1), 2022 |
Number 24 VOL. 24(2), 2021 |
Number 24 VOL. 24(1), 2021 |
Number 23 VOL. 23(2), 2020 |
Number 22 VOL. 22(2), 2019 |
Number 22 VOL. 22(1), 2019 |
Number 22 VOL. 22, 2019 Supplement |
Number 21 VOL. 21(2), 2018 |
Number 21 VOL. 21 (1), 2018 |
Number 21 VOL. 21, 2018 Supplement |
Number 20 VOL. 20 (2), 2017 |
Number 20 VOL. 20 (1), 2017 |
Number 19 VOL. 19 (2), 2016 |
Number 19 VOL. 19 (1), 2016 |
Number 18 VOL. 18 (2), 2015 |
Number 18 VOL. 18 (1), 2015 |
Number 17 VOL. 17 (2), 2014 |
Number 17 VOL. 17 (1), 2014 |
Number 16 VOL. 16 (2), 2013 |
Number 16 VOL. 16 (1), 2013 |
Number 15 VOL. 15 (2), 2012 |
Number 15 VOL. 15, 2012 Supplement |
Number 15 Vol. 15 (1), 2012 |
Number 14 14 - Vol. 14 (2), 2011 |
Number 14 The 9th Balkan Congress of Medical Genetics |
Number 14 14 - Vol. 14 (1), 2011 |
Number 13 Vol. 13 (2), 2010 |
Number 13 Vol.13 (1), 2010 |
Number 12 Vol.12 (2), 2009 |
Number 12 Vol.12 (1), 2009 |
Number 11 Vol.11 (2),2008 |
Number 11 Vol.11 (1),2008 |
Number 10 Vol.10 (2), 2007 |
Number 10 10 (1),2007 |
Number 9 1&2, 2006 |
Number 9 3&4, 2006 |
Number 8 1&2, 2005 |
Number 8 3&4, 2004 |
Number 7 1&2, 2004 |
Number 6 3&4, 2003 |
Number 6 1&2, 2003 |
Number 5 3&4, 2002 |
Number 5 1&2, 2002 |
Number 4 Vol.3 (4), 2000 |
Number 4 Vol.2 (4), 1999 |
Number 4 Vol.1 (4), 1998 |
Number 4 3&4, 2001 |
Number 4 1&2, 2001 |
Number 3 Vol.3 (3), 2000 |
Number 3 Vol.2 (3), 1999 |
Number 3 Vol.1 (3), 1998 |
Number 2 Vol.3(2), 2000 |
Number 2 Vol.1 (2), 1998 |
Number 2 Vol.2 (2), 1999 |
Number 1 Vol.3 (1), 2000 |
Number 1 Vol.2 (1), 1999 |
Number 1 Vol.1 (1), 1998 |
|
|