HUMAN LEUKOCYTE ANTIGEN-B27 AND DISEASE SUSCEPTIBILITY IN VOJVODINA, SERBIA
Vojvodić S1,*, Ademović-Sazdanić D1, Busarčević I2
*Corresponding Author: Assistant Professor Svetlana Vojvodić, M.D., Ph.D., Department for Laboratory Testing, Tissue Typing Compartment, Institute for Blood Transfusion of Vojvodina, Hajduk Veljkova 9a, 21000 Novi Sad, Serbia; Tel.: +381-21-4877-963; Mobile: +381-64-861-58-12; Fax: +381-21-4877-978; E-mail: ssvu@EUnet.rs
page: 55

RESULTS

Table 1 presents the distribution of HLA-B27 antigen in investigated subgroups of patients and controls from the Vojvodina population. It is noticeable that a significant increase in HLA-B27 frequency was found in the subgroup of patients with AS, 62.5% vs. 6.2% in controls, followed by the frequency of 18.1% in the patients with AAU, 12.5% in patients with synovitis coxae. The HLA-B27 frequency was similar in the patients with lumboischialgia (7.1%) and polyarthralgia (5.8%) compared to controls, while the frequencies found for the group of patients with PA and RA (33.3% for both subgroups) cannot reflect the real situation due to the small number of patients included in this study. Table 2 presents the result of calculated risk on disease susceptibility with HLA-B27. A relative risk higher than 1 was observed for subgroups of patients with AS (RR = 25.0), PA and RA (RR = 7.5 for both subgroups), AAU (RR = 3.33), synovitis coxae (RR = 2.142) and lumboishialgia (RR = 1.153), but positive association (EF greater than 0.15 ) was found in subgroups of patients with AS (EF = 0.600). For PA and RA subgroups, EF = 0.288 for both of groups, but the very small number of patients was an obstacle for accurate statistical analysis. A lower frequency of HLA-B27 antigen compared to the control group was found in the subgroup of patients with polyarthralgia (RR = 0.9375) (PF is lower than 0.15), but negative association was not statistically significant (χ2 is not greater than 3.841). The χ2 test showed the significant difference between HLA-B27 frequencies in the subgroups of patients with ankylosing spondylitis (χ2 = 52.5) and synovitis coxae (χ2 = 9.37), in comparison to controls. The χ2 values exceeding 3.841 (corresponding to p <0.05) were regarded as a stable borderline index for significant differences between HLA-B27 frequencies in controls and investigated subgroups of patients.



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