HUMAN LEUKOCYTE ANTIGEN-B27 AND
DISEASE SUSCEPTIBILITY IN VOJVODINA, SERBIA
Vojvodić S1,*, Ademović-Sazdanić D1, Busarčević I2
*Corresponding Author: Assistant Professor Svetlana Vojvodić, M.D., Ph.D., Department for Laboratory
Testing, Tissue Typing Compartment, Institute for Blood Transfusion of Vojvodina, Hajduk Veljkova 9a,
21000 Novi Sad, Serbia; Tel.: +381-21-4877-963; Mobile: +381-64-861-58-12; Fax: +381-21-4877-978;
E-mail: ssvu@EUnet.rs
page: 55
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Abstract
There are numerous studies showing the role
of human leukocyte antigens (HLAs) related with
susceptibility or resistance to certain diseases. The
aim of this study was to determine the association
of HLA-B27 with ankylosing spondylitis (AS), polyarthralgia,
lumboishialgia, acute anterior uveitis
(AAU), psoriatic arthritis (PA), synovitis coxae and
rheumatoid arthritis (RA) in patients from Vojvodina,
Serbia. An HLA I class typing was performed by the
serological immunomagnetic two-color fluorescence
method using peripheral blood T lymphocytes in 97
patients and 224 healthy controls from the population
of Vojvodina, Serbia.We calculated HLA-B27
frequencies, relative risk (RR), ethiologic fraction
(EF), e.g., population attributive risk, when RR was
greater than 1, while, preventive fraction (PF) was
calculated when RR was lower than 1. This study
revealed the strongest association of AS with HLAB27
antigen: RR = 25.0, while the EF was greater
than 0.15, respectively. The χ2 test showed the significant
difference (p <0.05) in HLA-B27 in patients
with AS in comparison to controls (χ2 = 52.5). It
was concluded that there is a positive association of
HLA-B27 with AS and that HLA-B27 can serve as
a marker for predisposition to diseases.
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