CYTOGENETIC FINDINGS IN MENTALLY
RETARDED IRANIAN PATIENTS
Nasiri F1, Mahjoubi F1,2,*, Manouchehry F1, Razazian F1, Mortezapour F1, Rahnama M1
*Corresponding Author: Dr. Frouzandeh Mahjoubi, Genetics Department, Iran Blood Transfusion Organization
Research Centre, High Institute for Research and Education in Transfusion Medicine, Hemmat Express Way, Next to
the Milad Tower, Tehran, Iran; Tel.: +9821-44580389; Fax: +9821-44580399; E-mail: Frouz@ nigeb.ac.ir
page: 29
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CONCLUSIONS
In conclusion, the results of this study illustrate
the contribution of chromosomal abnormalities to
the pathogenesis of MR in this group of mentally
retarded Iranian patients. Therefore, we recommend
cytogenetic analysis for every individual with idiopathic
MR.
This can help the management of the MR patient
much better. In addition, by discovering the cause of
MR, e.g., deletion or duplication/trisomy of a chromosomal
segment resulting from a paternal/maternal
balanced translocation, prenatal diagnosis could be
applied for future pregnancies, thus preventing the
birth of another MR infant(s) through therapeutic
abortion, which is allowed in Iran. Furthermore, since
a routine cytogenetic analysis gives a minimum resolution
of only 4-10 Mb, other advanced molecular
cytogenetic techniques would be helpful for the diagnosis
of the MR patients with normal karyotype,
as mentioned by some researchers [12,18].
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