CYTOGENETIC FINDINGS IN MENTALLY RETARDED IRANIAN PATIENTS
Nasiri F1, Mahjoubi F1,2,*, Manouchehry F1, Razazian F1, Mortezapour F1, Rahnama M1
*Corresponding Author: Dr. Frouzandeh Mahjoubi, Genetics Department, Iran Blood Transfusion Organization Research Centre, High Institute for Research and Education in Transfusion Medicine, Hemmat Express Way, Next to the Milad Tower, Tehran, Iran; Tel.: +9821-44580389; Fax: +9821-44580399; E-mail: Frouz@ nigeb.ac.ir
page: 29
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Abstract

We conducted a cytogenetic study on 865 individuals with idiopathic mental retardation (MR) who were admitted to the Cytogenetics Department of the Iran Blood Transfusion Organisation (IBTO) Research Centre, Tehran, Iran; these were performed on blood samples using conventional staining methods. Chromosome anomalies were identified in 205 of the patients (23.6%). The majority were Down’s syndrome cases (n = 138). In 33 males, a positive fragile X anomaly was found .The remainder (n = 34) had other chromosomal abnormalities including structural chromosome aberrations (n = 23), marker chromosomes with an unknown origin (n = 3), sex chromosome aneuploidy (n = 6) and trisomy 18 (n = 2). The contribution of chromosome aberrations to the cause of MR in this group of patients is discussed.



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