A PRELIMINARY microRNA ANALYSIS OF NON SYNDROMIC
THORACIC AORTIC ANEURYSMS
Patuzzo C1,*, Pasquali A1, Malerba G1, Trabetti E1,
Pignatti PF1, Tessari M2, Faggian G2
*Corresponding Author: Dr. Cristina Patuzzo, Department of Life and Reproduction Sciences, University
of Verona, Strada Le Grazie 8, 37134,Verona, Italy; Tel.: +39-45-802-7207; Fax: +39-45-802-7180; E-mail:
cristina.patuzzo@univr.it
page: 51
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RESULTS
The oligonucleotide probes on the microarrays
complemented 728 mature miRNAs. Differentially
expressed miRNAs ranged from –2.24-fold down
regulation to +7.20-fold up regulation, and are listed
in Table 1. Out of 728 miRNAs detected, 87 resulted
differentially expressed in males (11 down- and
76 up-regulated in TAA) and 28 in females (eight
down and 20 up-regulated in TAA), compared to
their controls. Five and 11 of these miRNAs were
down and up regulated in both male and female TAAs, respectively, for a total of 16 sex-insensitive
differentially expressed miRNAs. No miRNA was
regulated in the opposite direction in one sex compared
to the other.
Table 2 shows the most interesting coordinated
gene expression pathways resulting from Diana
mirPath software analysis. A multiple testing correction
was performed according to Bonferroni’s
method [14], as indicated in Table 2. Focal adhesion
was the most gene enriched pathway. It was putatively
targeted by the 11 sex-insensitive up-regulated
miRNAs (adjusted p value 5.43E-09). Adherens
junction-related genes were also preferentially indicated,
putatively targeted by the five sex-insensitive
down-regulated miRNAs (adjusted p value 7.12E-
06) and apparently also by the up-regulated miRNAs
(adjusted p value 2.56E-04). Another significant
pathway was the regulation of actin cytoskeleton
(adjusted p value 3.12E-04) that resulted from
up-regulated miRNAs analysis.
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