A PRELIMINARY microRNA ANALYSIS OF NON SYNDROMIC
THORACIC AORTIC ANEURYSMS
Patuzzo C1,*, Pasquali A1, Malerba G1, Trabetti E1,
Pignatti PF1, Tessari M2, Faggian G2
*Corresponding Author: Dr. Cristina Patuzzo, Department of Life and Reproduction Sciences, University
of Verona, Strada Le Grazie 8, 37134,Verona, Italy; Tel.: +39-45-802-7207; Fax: +39-45-802-7180; E-mail:
cristina.patuzzo@univr.it
page: 51
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Abstract
The development of thoracic aortic aneurysms
(TAAs) involves a multifactorial process resulting
in alterations of the structure and composition of
the extracellular matrix (ECM). Recently, modifications
in microRNA (miRNA) expression were implicated
in the pathogenesis of TAA.
This study presents a preliminary miRNA microarray
analysis conducted on pooled ascending
aorta RNAs obtained from non familial non syndromic
TAA patients (five males and five females)
compared to matched control pools. Ninety-nine
differentially expressed miRNAs with >1.5-foldup-
or down-regulation in TAAs compared to controls
were identified, 16.0% of which were similarly
regulated in the two sexes.
Genes putatively targeted by differentially expressed
miRNAs belonged preferentially to focal
adhesion and adherens junction pathways. The results
indicate an altered regulation of miRNA-mediated
gene expression in the cellular interactions of
aneurysmal aortic wall.
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