A PRELIMINARY microRNA ANALYSIS OF NON SYNDROMIC THORACIC AORTIC ANEURYSMS
Patuzzo C1,*, Pasquali A1, Malerba G1, Trabetti E1, Pignatti PF1, Tessari M2, Faggian G2
*Corresponding Author: Dr. Cristina Patuzzo, Department of Life and Reproduction Sciences, University of Verona, Strada Le Grazie 8, 37134,Verona, Italy; Tel.: +39-45-802-7207; Fax: +39-45-802-7180; E-mail: cristina.patuzzo@univr.it
page: 51
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Abstract

The development of thoracic aortic aneurysms (TAAs) involves a multifactorial process resulting in alterations of the structure and composition of the extracellular matrix (ECM). Recently, modifications in microRNA (miRNA) expression were implicated in the pathogenesis of TAA. This study presents a preliminary miRNA microarray analysis conducted on pooled ascending aorta RNAs obtained from non familial non syndromic TAA patients (five males and five females) compared to matched control pools. Ninety-nine differentially expressed miRNAs with >1.5-foldup- or down-regulation in TAAs compared to controls were identified, 16.0% of which were similarly regulated in the two sexes. Genes putatively targeted by differentially expressed miRNAs belonged preferentially to focal adhesion and adherens junction pathways. The results indicate an altered regulation of miRNA-mediated gene expression in the cellular interactions of aneurysmal aortic wall.



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