Balkan Journal of Medical Genetics

Possible association of maternal haemorrhoid with congenital abnormalities in their children – a population-based case-control study
Ferenc Bánhidy, M.D.1, Nándor Ács, M.D.1, Erzsébet H. Puhó2, and Andrew E. Czeizel2*
*Corresponding Author: Andrew E. Czeizel, Foundation for the Community Control of Hereditary Diseases, 1026 Budapest, Törökvész lejtõ 32. Hungary; Tel: +36 1 3944 712, Fax: +36 1 3944 712; E-mail: czeizel@interware.hu
page: 25

Statistical Methods

SAS version 8.02 (SAS Institute Ins., Cary, North Carolina, USA) was used for statistical analyses. First the main maternal and newborn variables were evaluated in case and control pregnant women with or without haemorrhoid as reference using Student t test for quantitative chi square test for categorical variables. The occurrence of pregnancy complications, other maternal diseases and drug intakes during pregnancy, were compared between the case and the control mothers with haemorrhoid using crude odds ratios (OR) with 95% confidence intervals (CI). The occurrence of haemorrhoid in the mothers of cases with specific CA groups and in the mothers of all matched controls WAS compared in conditional logistic regression models and adjusted OR with 95% CI WAS calculated for estimating of association of maternal haemorrhoid with CA in their children. The bias connected with multiple testing was limited by the use of the Bonferroni method [12].

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