ANXA5 AND VEGFA GENE VARIANTS
IN WOMEN WITH EARLY PREGNANCY LOSSES
FROM NORTH MACEDONIA
Terzikj M, Bozhinovski Gj, Branoski A, Dimkovska M, Kubelka-Sabit K, Plaseska-Karanfilska D
*Corresponding Author: Corresponding author, Prof. Dijana Plaseska-Karanfilska, MD, PhD.
Research Centre for Genetic Engineering and Biotechnology “Georgi D. Efremov”,
Macedonian Academy of Science and Arts, Skopje, North Macedonia, e-mail: dijana@manu.edu.mk
page: 5
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Abstract
Early pregnancy loss (EPL) is the most common preg-
nancy complication, found in approximately 15% of all
clinically recognized pregnancy complications. Up to date,
various maternal as well as fetal factors are reported as a
cause of EPLs. However, in approximately 50% of EPL
cases, the exact cause is not clearly identified and these
cases are referred as idiopathic.
The aim of our study was to examine the association
of four distinct variants in the ANXA5 gene and two vari-
ants within the VEGFA gene in a cohort of women with
EPLs from North Macedonia. This group was compared
to a control group of women matched by ethnic back-
ground without pregnancy loss and at least one live birth.
We also aimed to establish an effective and cost-efficient
method for their detection based on multiplex single-base
extension.
Among 190 women experiencing EPLs, and 190
samples from women without a history of pregnancy loss
(control group), our results demonstrated a statistically
significant prevalence of heterozygotes for the M2/ANXA5
haplotype in women with EPLs, compared to the control
group (p=0.0006). In the analyses comparing genotypic
frequencies for the variants in the VEGFA gene, higher
frequencies were generally observed among women ex-
periencing EPLs, however without statistical significance.
Our study aligns with multiple studies showing that
M2 and M1 ANXA5 haplotypes are more prevalent inpatients with pregnancy loss and presents an affordable
genotyping technique for the specific ANXA5 and VEGFA
variants.
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