ADIPOCYTE “FATTY ACID BINDING PROTEIN”
GENE POLYMORPHISMS (rs1054135, rs16909196
AND rs16909187) IN JORDANIANS WITH OBESITY
AND TYPE 2 DIABETES MELLITUS
El-Ryalat S.W.1, Irshaid Y.M.1*, Abujbara M.2, El-Khateeb M.2, Ajlouni K.M.2
*Corresponding Author: Prof. Yacoub M. Irshaid MD, PhD, Department of Pharmacology, College of
Medicine, The University of Jordan, Amman 11942, Jordan. Phone No.: +962 777818284,
Fax No.: +962 6 5300820, Email Addresses: y.irshaid@ju.edu.jo
page: 63
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Abstract
Background: Obesity, type 2 diabetes mellitus
(T2DM), and dyslipidemia may result from the interactions
of genetic and environmental factors. There are controversial
reports concerning the association of polymorphisms
(rs1054135, rs16909196 and rs16909187) in the gene of
adipocyte fatty acid binding protein (FABP4) with obesity
and T2DM. Therefore, we designed this study to determine
the association of these polymorphisms with obesity,
T2DM, and dyslipidemia among Jordanian subjects.
Methods: The study was approved by the National
Center for Diabetes, Endocrinology, and Genetics
(NCDEG) Institutional Review Board (IRB). A total of
397 subjects were enrolled in the study and divided into
four groups as described in materials and methods section.
The fatty acid binding protein 4 (FABP4) gene containing
(rs1054135, rs16909196 and rs16909187) single nucleotide
polymorphisms (SNP) was amplified by polymerase
chain reaction (PCR) followed by Sanger DNA sequencing
of the PCR product.
Results: None of the three SNPs were associated
with T2DM (p > 0.05). The rs16909187 and rs16909196
were significantly associated with obesity. The wild type
(CC) of rs16909187 was significantly higher among the
overweight and obese group compared with normal weight
controls (OD = 2.17, 95% CI = 1.18 - 3.96, p =0.01). The
wild type of rs16909196 (AA) was significantly higher
among the overweight and obese group compared to controls,
(OD = 2.26, 95% CI = 1.24 - 4.14, p = 0.01). These
results may indicate that the wild-type may be a risk factor
for obesity.
Only the rs1054135 SNP was significantly associated
with increased low density lipoprotein (LDL) levels in the
overweight and obese group compared with the controls
(p = 0.03).
Conclusions: The wild-type genotypes of rs16909196
and rs16909187 may be risk factors for obesity but not
T2DM. None of the three SNPs was associated with
T2DM.
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