RISK FACTORS OF VENOUS THROMBOEMBOLISM
IN SUDANESE PREGNANT WOMEN
Abdalhabib EK, Alfeel A, Ali EI, Ibrahim IK, Mobarki AA, Dobie G, Hamali HA, Saboor M,
*Corresponding Author: Dr. Muhammad Saboor, Department of Medical Laboratory Technology,
Faculty of Applied Medical Science, Jazan University, Jazan, Saudi Arabia. Tel.: +966-54-495-9029.
E-mail: msaboor@ jazanu.edu.sa
page: 49
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Abstract
Venous thromboembolism (VTE) is one of the major
causes of pregnancy-related mortality and morbidity. This
study aimed to determine the frequency of factor V Leiden
(FVL) and prothrombin G20210A polymorphisms and
measure the plasma levels of protein C (PC), protein S (PS)
and antithrombin (AT) in pregnant women with VTE and
healthy pregnant women. This prospective case-control
study determined the frequencies of FVL G1691A and
prothrombin G20210A polymorphisms and measured the
plasma levels of PC, PS and AT in 198 pregnant women
with VTE and 198 healthy pregnant women. Allele-specific
polymerase chain reaction (ASPCR) was used to
detect the FVL G1691A polymorphisms and prothrombin
G20210A gene mutations. The FVL G1691A polymorphism
and prothrombin G20210A gene mutations were
detected only in pregnant women with VTE, with frequencies
of 4.0 and 0.5%, respectively. The highest frequency
of FVL G1691A polymorphism was observed in patients
with deep vein thrombosis (DVT) and positively associated
with contraceptive use and termination. Pregnant women
with VTE had significantly lower levels of PC, PS and
AT than those of controls. In conclusion, among the VTE
cases, FVL G1691A polymorphism and PC, PS and AT
deficiencies were the most common findings in patients
presenting with DVT. Antithrombin deficiency was more
common than PC and PS deficiencies. Contraceptive use,
high body mass index (BMI) and termination correlated
strongly with FVL G1691A polymorphism and PC and PS
deficiencies in patients with VTE.
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