ASSOCIATION OF GENETIC POLYMORPHISMS IN
THE Matrix Gla Protein (MGP) GENE WITH CORONARY
ARTERY DISEASE AND SERUM MGP LEVELS
Karsli-Ceppioglu S1,*, Yazar S2, Keskin Y3, Karaca M4, Luleci NE3, Yurdun T1
*Corresponding Author: Seher Karsli-Ceppioglu, Ph.D., Department of Toxicology, Faculty of Pharmacy,
Marmara University, Tibbiye Street No. 49, İstanbul 34668, Turkey. Tel: +90-216-414-2962.
Fax: +90-216-345-2952. E-mail: seher.karsli@marmara.edu.tr
page: 43
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Abstract
Matrix Gla protein (MGP) is an important regulatory
protein for inhibition of calcification in the vessel wall and
cartilage. The MGP gene polymorphisms are suspected to
increase the risk of extracellular calcification through altering
the related gene expression and serum MGP levels. The
goal of this study was to examine the correlation between
rs4236 (Thr83-Ala), rs12304 (Glu60-X) and rs1800802
(T138-C) polymorphisms of the MGP gene and coronary
artery calcification. Serum MGP levels of 168 subjects who
had undergone coronary angiography were analyzed along
with genotyping of MGP gene polymorphisms. The results
indicated that serum MGP levels were significantly associated
with rs4236 and rs1800802 polymorphisms of the
MGP gene with the occurrence of coronary artery diseases
(CAD). Allelic distributions of MGP gene polymorphisms
and serum MGP levels, respectively, were not significantly
interconnected with the presence of CAD. Our results
revealed that serum MGP levels of CAD patients show
association with rs4236 and rs1800802 polymorphisms,
but serum MGP levels alone do not directly reflect the risk
of CAD. The role of MGP genetic variants on formation
and progression of arterial calcification should be regarded
in cardiovascular diseases.
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