THE ROLE OF RNA METABOLISM IN NEUROLOGICAL DISEASES
Alaqeel AM1,2,*, Abou Al-Shaar H3, Shariff RK3, Albakr A2
*Corresponding Author: Ahmed M. Alaqeel, M.D., Department of Neurosurgery, University of Calgary, 1403 29th Street NW, Calgary, Alberta T2N 2T9, Canada. Tel: +403-970-9117. Fax: +403-270-7878. E-mail: ahmedalaqeel@hotmail.com
page: 5
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Abstract

Neurodegenerative disorders are commonly encountered in medical practices. Such diseases can lead to major morbidity and mortality among the affected individuals. The molecular pathogenesis of these disorders is not yet clear. Recent literature has revealed that mutations in RNA-binding proteins are a key cause of several human neuronal-based diseases. This review discusses the role of RNA metabolism in neurological diseases with specific emphasis on roles of RNA translation and microRNAs in neurodegeneration, RNA-mediated toxicity, repeat expansion diseases and RNA metabolism, molecular pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia, and neurobiology of survival motor neuron (SMN) and spinal muscular atrophy.



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