ANALYSIS OF MICROSATELLITE POLYMORPHISMS
IN SOUTH INDIAN PATIENTS WITH NON SYNDROMIC
CLEFT LIP AND PALATE
Xavier DL1,* Arif YA1, Murali RV1, Kishore Kumar S1,
Vipin Kumar S2, Tamang R2, Thangaraj K2, Bhaskar LVKS3
*Corresponding Author: Dr. Dhayananth L. Xavier, Department of Orthodontics, Sree Balaji Dental College,
Pallikaranai, Chennai, India; Tel.: +91-44-22461883; E-mail: drxavy@gmail.com
page: 49
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Abstract
Non syndromic cleft lip and/or palate (NSCLP) is
a complex congenital anomaly with varying incidence
among patients of different geographical origins.
Multiple contributing factors are known to trigger
the cleft formation. There are several genes involved
in the aetiology of NSCLP and they are different in
different populations. The genetic components of
clefts that underlie the susceptibility to respond to
the environment still remain unclear. In this study,
five microsatellite polymorphisms from five candidate
genes were employed to analyze the association
between these genes and NSCLP in 83 patients and
90 controls. Genotyping was performed by separating
and visualizing the fluorescently-labeled polymerase
chain reaction (PCR) products. The association of the
five microsatellite polymorphisms with NSCLP was
tested by using the CLUMP v1.9 program that uses
the Monte Carlo method. The genotypic distribution
is in Hardy-Weinberg equilibrium in the control group
for only the MSX1 and DLX3 genes. The RARA microsatellite
was significantly associated with NSCLP.
Our results suggest that the RARA gene is involved in
pathogenesis of cleft lip and palate in South Indians
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