ANALYSIS OF MICROSATELLITE POLYMORPHISMS IN SOUTH INDIAN PATIENTS WITH NON SYNDROMIC CLEFT LIP AND PALATE
Xavier DL1,* Arif YA1, Murali RV1, Kishore Kumar S1, Vipin Kumar S2, Tamang R2, Thangaraj K2, Bhaskar LVKS3
*Corresponding Author: Dr. Dhayananth L. Xavier, Department of Orthodontics, Sree Balaji Dental College, Pallikaranai, Chennai, India; Tel.: +91-44-22461883; E-mail: drxavy@gmail.com
page: 49
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Abstract

Non syndromic cleft lip and/or palate (NSCLP) is a complex congenital anomaly with varying incidence among patients of different geographical origins. Multiple contributing factors are known to trigger the cleft formation. There are several genes involved in the aetiology of NSCLP and they are different in different populations. The genetic components of clefts that underlie the susceptibility to respond to the environment still remain unclear. In this study, five microsatellite polymorphisms from five candidate genes were employed to analyze the association between these genes and NSCLP in 83 patients and 90 controls. Genotyping was performed by separating and visualizing the fluorescently-labeled polymerase chain reaction (PCR) products. The association of the five microsatellite polymorphisms with NSCLP was tested by using the CLUMP v1.9 program that uses the Monte Carlo method. The genotypic distribution is in Hardy-Weinberg equilibrium in the control group for only the MSX1 and DLX3 genes. The RARA microsatellite was significantly associated with NSCLP. Our results suggest that the RARA gene is involved in pathogenesis of cleft lip and palate in South Indians



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