MicroRNAs IN BREAST CANCER —OUR INITIAL RESULTS
Popovska-Jankovic K1, Noveski P1, Chakalova L1, Petrusevska G2, Kubelka K3,
Plaseska-Karanfilska D1
*Corresponding Author: Professor Dr. Dijana Plaseska-Karanfilska, Research Centre for Genetic
Engineering and Biotechnology “Georgi D. Efremov,” Macedonian Academy of Sciences and Arts, Krste
Misirkov 2, Skopje 1000, Republic of Macedonia; Tel: +389(0)2 3235410; Fax: +389 (0)2 3115434; E-mail:
dijana@manu.edu.mk
page: 87
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Abstract
MicroRNAs (miRNAs) are small [~21 nucleotide
(nt)] non coding RNAs (ncRNAs) that regulate
gene expression posttranscriptionally. About
3.0% of human genes encode for miRNAs, and up
to 30.0% of human protein coding genes may be
regulated by miRNAs. Currently, more than 2000
unique human mature microRNAs are known.
MicroRNAs play a key role in diverse biological
processes including development, cell proliferation,
differentiation and apoptosis. These processes
are commonly dysregulated in cancer, implicating
miRNAs in carcinogenesis, where they act as tumor
supressors or oncogenes. Several miRNAs are associated
with breast cancer. Here we present our initial
results of miRNA analyses of breast cancer tissues
using quantitative real time-polymerase chain
reaction (ReTi-PCR) (qPCR) involving stem-loop
reverse transcriptase (RT) primers combined with
TaqMan® PCR and miRNA microarray analysis.
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