IL-18 GENE PROMOTER REGION 607C/A POLYMORPHISM
IN HIV-1 INFECTED NORTH INDIAN POPULATION
Sobti RC1,*, Sharma VL2, Abitew AM2, Berhane N1,
Mahdi SA1, Askari M1, Kuttiat VS3, Wanchu A3
*Corresponding Author: Ranbir C. Sobti, Department of Biotechnology, Panjab University, Chandigarh 160
014 India; Tel.: +172-2534087; +94-1-704-4523; Fax: +172-25341409; E-mail: rcsobti@ pu.ac.in
page: 41
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Abstract
Several host genetic factors play an important
role in susceptibility to human immunodeficiency virus
type 1 (HIV-1) infection and in its progression to
acquired immune deficiency syndrome (AIDS). The
interleukin-18 (IL-18) is a multifunctional proinflammatory
cytokine that regulates immune responses and
plays a pathogenic role in HIV-1 infection by enhancing
viral replication. Single nucleotide polymorphisms
(SNPs) in the IL-18 gene promoter region may lead to
altered transcriptional activity and IL-18 production,
and may account for variation in the risk of HIV-1 infection.
We have investigated the association between
IL-18 promoter polymorphism −607C>A and HIV-1
infection through a case-control study of 500 patients
with HIV-1/AIDS and an equal number of age and sex
matched controls in a north Indian population. Genotyping
using sequence specific primer-polymerase
chain reaction (SSP-PCR) showed a statistically significant
reduced risk of HIV-1 infection for the A>A
genotype [odds ratio (OR) = 0.57, 95% confidence interval
(95% CI) = 0.33-0.98, p = 0.040], but not for the
C>A genotype (OR = 0.87, 95% CI = 0.66-1.14, p =
0.321). We concluded that the −607A allele of the IL-
18 gene promoter polymorphism may play a protective
role against the progression of HIV-1 infection in this
population.
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