CHROMOSOMAL ABNORMALITIES IN ENDOMETRIAL AND OVARIAN CARCINOMAS
PazarbaÕi A1,*, Kasap M1, Demirhan O1, Vardar MA2, Suleymanova-Karahan D1, Doran F3
*Corresponding Author: *Corresponding Author: Ayfer PazarbaÕi, Ph.D., Department of Medical Biology and Genetics, University of Çukurova, School of Medicine, 01330 Balcali, Adana, Turkey; Tel.: +90-322-338-70-68; Fax: +90-322-338-65-72; E-mail: payfer@cu.edu.tr
page: 61

Abstract

 

Development and progression of human malignancies involve multiple genetic changes including chromosomal instabilities such as translocations, deletions, and inversions. Chromosomal abnormalities were observed in 23 cases with ovarian and endometrial cancer by cytogenetic studies using a GTG (G bands by trypsin using Giemsa) banding technique. Specific chromosome bands were frequently involved, and were most frequent on chromosomes 1, 2, 3, 5, 12 and 17. Clonal alterations were observed at the cancer breakpoints, such as 1q21, 1q32, 3p21, 7q22, 11q23 in ovarian and 1p36, 1q32, 2p12, 3p21, 7q22, 9q34, 11p15, 11q23, 12q13, 14q11, 14q32, 16p13, 21q22 in endometrial cases. These findings provide evidence that multiple genetic lesions are associated with the patho genesis of endometrial and ovarian cancer.

Key words: Endometrial cancer, Ovarian cancer, Cytogenetics






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