THERE IS NO ASSOCIATION BETWEEN THE 318 (C→T) AND +49 (A→G) CTLA4 GENE POLYMORPHISMS AND THE COELIAC CONDITION IN THE MALTESE POPULATION
Borg J1,*, Scerri CA1,3, Vidal C2, Xuereb Anastasi A1,2
*Corresponding Author: Joseph Borg, B.Sc (Hons) MLS, Laboratory of Molecular Genetics, Department of Physiology and Biochemistry, Biomedical Science Building, University of Malta, Msida, Malta; Tel.: +356-2340-2774, Fax: +356-2134-3535, E-mail: joseph.borg@biotech.um.edu.mt
page: 49

Abstract

The coeliac condition (CD) has an autoimmune com­ponent in genetically predisposed individuals which is triggered by the gliadin component of gluten found in wheat. The CD manifests itself in partial or total villus destruction of the small intestine with consequent malab­sorption and malnutrition. The main triggering factor is a transglutaminated peptide within the gliadin component of wheat gluten. An established HLA component is respon­sible for about 35% of the genetic predisposition. The 318 (C→T) and +49 (A→G) single nucleotide polymor­phisms (SNPs) were studied in 100 biopsy-confirmed coeliac patients and in 187 DNA samples from neonatal controls representing a random number of the Maltese population. No association of the SNPs or the combined haplotypes was apparent amongst the CD patients. The 318 C allele and the +49 A allele were in linkage disequi­librium in the neonatal samples.

      Key words: Coeliac condition (CD); CTLA4; Linkage disequilibrium.

 

__________________________________________________

1 Institute of Health Care, University of Malta, Guardamangia, Malta

      2 Department of Pathology, University of Malta Medical School, Guardamangia, Malta

      3 Laboratory of Molecular Genetics, Department of Physiol­ogy and Biochemistry, University of Malta, Msida, Malta

 

 




Number 20
VOL. 20 (1), 2017
Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006