THE ANALYSIS OF MICRONUCLEI FREQUENCY IN A CONTROL SAMPLE, AND IN HORMONALLY- TREATED FEMALE PATIENTS ATTENDING THE KRAGUJEVAC HOSPITAL, SERBIA, YUGOSLAVIA
Milosevic-Djordjevic O1, Grujicic D1, Marinkovic D2, Arsenijevic S3, Joksic G4, Jankovic S5
*Corresponding Author: Dr. Olivera Milosevic-Djordjevic, Faculty of Sciences, University of Kragujevac, Institute of Biology, Department of Genetics, Radoja Domanovica 12, P.O. Box 60, 34000 Kragujevac, Serbia, Yugoslavia; Tel: +381-34-336-223 to 330; Fax: +381-34-335-040; E-mail: darko@knez.uis.kg.ac.yu
page: 37

Abstract

The aim of this paper was to obtain the precise answer about the effect of therapy by gestagens, that are intensively applied to prevent threatening spontaneous abortions. The frequency of micronuclei (MN) in samples from patients to whom appropriate therapy has been applied during the first 3 months of pregnancy was analyzed. The samples were from 29 phenotypically healthy pregnant women, average age of 26  1 years; frequency of MN was determined before and after the end of therapy. Gestormone, Progesterone depo and Gravibinone have increased MN frequency significantly, with a probability of p<0.05, and Utrogestane has also increased MN frequency, but without statistical significance (p<0.1). ANOVA showed that the mentioned gestagens increase variability of MN frequency, with high statistical significance (F = 8.63; p<0.0048). Environmental factors (79%) influence the formation of MNs and their variability in great proportion.

Key words: gestagens, in vivo, lymphocytes, micronucleus, pregnancy, variability.




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