THE TNFα GENE G(308)A POLYMORPHISM AS A MARKER FOR MYOCARDIAL INFARCTION IN TYPE 2 DIABETES MELLITUS
Reschner H1**, Steblovnik K2**, Milutinović A2, Petrovič D,2*
*Corresponding Author: Professor Dr. Danijel Petrovič, Institute of Histology and Embryology, Medical Faculty, University of Ljubljana, Korytkova 2, Ljubljana 1000, Slovenia; Tel.: +386-1- 543-73-67; Fax: +386-1-543-73-61; e-mail: Daniel.Petrovic@mf.uni-lj.si
page: 11

RESULTS

The characteristics of the patients studied are summarized in Table 1. The patients with MI were younger, predominantly male and had a higher incidence of cigarette smoking than those without MI. They also had higher total cholesterol and LDL cholesterol levels, and longer duration of DM2 (Table 1). There were no significant differences in the incidence of hypertension, HDL cholesterol and triglyceride levels between the two groups (Table 1).

      The frequency of the G(308)A polymorphism is shown in Table 2. These were compatible with the Hardy-Weinberg expectations. There was no association between the polymorphism and MI in DM2 patients (OR = 0.8, 95% CI = 0.5-1.3, p = 0.4 for the recessive model and OR = 0.8, 95% CI = 0.2-2.8, p = 0.7 for the dominant model). The allele frequencies in patients with MI were: G 247 (87.0%) and A 37 (13.0%), and allele frequencies in patients without MI were: G 550 (88.7%) and A 70 (11.3%); the difference was not statistically significant.

            We analyzed serum TNFa levels in 70 consecutive DM2 patients. Significantly higher levels were found in 58 patients with the GG genotype compared to 12 patients with the AG genotype (1.13 0.6 ng/L vs. 0.53 0.35 ng/L:, p <0.01). We found no statistically significant differences between 10 DM2 patients with MI and 60 DM2 patients without MI [0.61 0.528 ng/L vs. 1.10 1.23 ng/L, p = no significance (n.s.)]. Moreover, we failed to demonstrate statistically significant differences in serum TNFa levels between eight smokers and 62 non smokers (1.35 0.8 ng/L vs. 1.11 1.22 ng/L, p = n.s.). Similarly, no statistically significant correlation between age and serum TNFa levels were demonstrated (p = 0.9, correlation coefficient = 0.004).



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