INTERLEUKIN-1β AND TUMOR NECROSIS FACTOR-α GENE POLYMORPHISMS IN SYSTEMIC SCLEROSIS
Hakami M.A1, Alotaibi B.S1, Alkhalil S.S1, Das S2, Nasreen N3, Jeraiby M.A4, Jawed A5, Lohani M5, Dar S.A5*
*Corresponding Author: *Corresponding Author: Sajad Ahmad Dar, Department of Nursing, College of Nursing and Health Sciences, Jazan University, Jazan – 45142, Saudi Arabia; Email: sdar@jazanu.edu.sa
page: 59
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CONCLUSION
Our study found a significant association between
IL-1β -511, +3962, and TNF-α -308, -238 SNPs and SSc
in our population, consistent with previous research linking
these SNPs to SSc susceptibility and progression. Larger,
more balanced studies are needed to confirm these associa-
tions. Future research should focus on the functional roles
of these SNPs through in vitro studies, genome editing,
and longitudinal cohort studies to better understand their
impact on disease progression and treatment outcomes.
Author Statement
The manuscript represents original, unpublished ma-
terial not under editorial consideration elsewhere, and
that ethical guidelines were followed in the conduct of
the research.
Acknowledgements
None
Conflict of Interest
The authors have no conflict of interest to disclose.
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