HIGH-RESOLUTION HLA-DRB1 ALLELE FREQUENCIES IN A ROMANIAN COHORT OF STEM CELL DONORS
Caragea лю, Ursu IR, Visan DL, Maruntelu I, Iordache P, Constantinescu A, Tizu M, Tălăngescu A, Constantinescu I
*Corresponding Author: Lect., MD, PhD Radu-Ioan Ursu, Carol Davila University of Medicine and
Pharmacy, Department of Medical Genetics, Bucharest, Romania, Str. Batistei 12, Bucharest, Romania; tel.: 0040736167020; e-mail: dr.radu.ursu@gmail.com
page: 43
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CONCLUSIONS
The current research provides important data on the
HLA-DRB1 alleles frequencies among the Romanian
population.
As expected and observed in previous studies, there
are similarities and disparities when it comes to the more
common and less frequent alleles between our analyzed
cohort and the various European and non-European popula-
tions. Important similarities can be observed with different
populations from Eastern Europe, the Balkans and Cauca-
sus regions, possibly indicating a common genetic ances-
try (documented by archaeological and historical data),
while the Central and Western European countries show a
constantly different constellation of HLA-DRB1 variants.
Further studies are needed for confirming and
strengthening the findings of this research for the Roma-
nian population.
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