Balkan Journal of Medical Genetics

ASSOCIATION BETWEEN THE POLYMORPHISM OF ANGIOTENSIN-CONVERTING ENZYME GENE AND INTERLEUKIN-1 BETA GENE AND THE RESPONSE TO ERYTHROPOIETIN THERAPY IN DIALYSIS PATIENTS WITH ANEMIA
Dzekova-Vidimliski P, Eftimovska-Otovikj N, Nikolov I G, Selim Gj, Rambabova-Bushljetik I, Pushevski V, Karanfilovski V, Matevska-Geshovska N, Dimovski A
*Corresponding Author: Assoc. Prof. Pavlina Dzekova-Vidimliski, MD, PhD, University Hospital for Nephrology, Mother Theresa str 17, 1000 Skopje, R. North Macedonia, Email address: pavlinadzekova@yahoo.com
page: 27

RESULTS

The study included 69 patients, 63 patients on mainte- nance hemodialysis, and 6 patients on peritoneal dialysis. Among the patients, 48 (69.5%) were male, and 21 (30.5%) were female. The etiology of kidney disease in most of the patients was chronic glomerulopathy (n = 21, 30.5%). The other etiological causes for kidney disease were: ob- structive nephropathy (n = 16, 23.2%), nephroarteriolo- sclerosis (n = 14, 20.3%), autosomal dominant polycystic kidney disease (n = 7, 10.1%), and unknown cause (n = 11, 15.9%). Demographic characteristics, dialysis vintage, laboratory parameters, and erythropoietin resistance index (ERI) of all study patients are presented in Table 1. The mean hemoglobin value in all patients was 109.4 ± 11.1 g/l, achieved by the application of an average of 6909 IU of erythropoietin per week. The mean value of TSAI (%) was 29.4 ± 7.6%, and the mean value of the fer- ritin was 468.8 ± 343.1 µg/l. The mean value of calculated erythropoietin resistance index (ERI) was 9.6 ± 6.2 IU kg/ week/dl, Table 1. The concentration of hemoglobin ≥ 110 g/l was registered in 37 (53.6%) patients, Table 2. Patients with hemoglobin ≥ 110 g/l were characterized with signifi- cantly higher serum levels of albumin, cholesterol, and iron compared to the patients with hemoglobin < 110 g/l. The serum levels of the CRP, the weekly dose of rHuEPO, and ERI were significantly higher in patients with hemo- globin < 110 g/l compared to patients with hemoglobin ≥ 110 g/l, Table 2. The ERI ≥ 10 IU/kg/week/g/dl was detected in 27 (39.1%) patients. Patients with ERI ≥10 IU/kg/week/g/dl had significantly lower levels of hemoglobin, cholesterol, iron, and TSAI% compared to patients with ERI< 10 IU/ kg/week/g/dl. The serum levels of ferritin and CRP, and a weekly dose of erythropoietin were significantly higher in patients with ERI ≥ 10 IU/kg/week/g/dl compared to patients with ERI <10 IU/kg/week/g/dl, Table 3. The polymorphism of the ACE gene (ACE I/D, rs1799752) is presented by three genotypes: ACE II, ACE ID, and ACE DD. The ACE ID genotype was with the highest frequency, at 59.4%, detected in 41 patients. There was no significant difference in ERI between the three genotypes of the ACE I/D, Table 4. The polymorphism of the IL-1b gene (IL-1B-511 C/T, rs1143627) is presented with three different genotypes: IL- 1B CC, IL-1B CT, and IL-1B TT. The IL-1B CT genotype was with the highest frequency of 50.7%, detected in 35 patients. There was no significant difference in ERI be- tween the three genotypes of the IL-1B-511 C/T, Table 5.

Number 27 VOL. 27 (2), 2024	Number 27 VOL. 27 (1), 2024
Number 26 Number 26 VOL. 26(2), 2023 All in one	Number 26 VOL. 26(2), 2023
Number 26 VOL. 26, 2023 Supplement	Number 26 VOL. 26(1), 2023
Number 25 VOL. 25(2), 2022	Number 25 VOL. 25 (1), 2022
Number 24 VOL. 24(2), 2021	Number 24 VOL. 24(1), 2021
Number 23 VOL. 23(2), 2020	Number 22 VOL. 22(2), 2019
Number 22 VOL. 22(1), 2019	Number 22 VOL. 22, 2019 Supplement
Number 21 VOL. 21(2), 2018	Number 21 VOL. 21 (1), 2018
Number 21 VOL. 21, 2018 Supplement	Number 20 VOL. 20 (2), 2017
Number 20 VOL. 20 (1), 2017	Number 19 VOL. 19 (2), 2016
Number 19 VOL. 19 (1), 2016	Number 18 VOL. 18 (2), 2015
Number 18 VOL. 18 (1), 2015	Number 17 VOL. 17 (2), 2014
Number 17 VOL. 17 (1), 2014	Number 16 VOL. 16 (2), 2013
Number 16 VOL. 16 (1), 2013	Number 15 VOL. 15 (2), 2012
Number 15 VOL. 15, 2012 Supplement	Number 15 Vol. 15 (1), 2012
Number 14 14 - Vol. 14 (2), 2011	Number 14 The 9th Balkan Congress of Medical Genetics
Number 14 14 - Vol. 14 (1), 2011	Number 13 Vol. 13 (2), 2010
Number 13 Vol.13 (1), 2010	Number 12 Vol.12 (2), 2009
Number 12 Vol.12 (1), 2009	Number 11 Vol.11 (2),2008
Number 11 Vol.11 (1),2008	Number 10 Vol.10 (2), 2007
Number 10 10 (1),2007	Number 9 1&2, 2006
Number 9 3&4, 2006	Number 8 1&2, 2005
Number 8 3&4, 2004	Number 7 1&2, 2004
Number 6 3&4, 2003	Number 6 1&2, 2003
Number 5 3&4, 2002	Number 5 1&2, 2002
Number 4 Vol.3 (4), 2000	Number 4 Vol.2 (4), 1999
Number 4 Vol.1 (4), 1998	Number 4 3&4, 2001
Number 4 1&2, 2001	Number 3 Vol.3 (3), 2000
Number 3 Vol.2 (3), 1999	Number 3 Vol.1 (3), 1998
Number 2 Vol.3(2), 2000	Number 2 Vol.1 (2), 1998
Number 2 Vol.2 (2), 1999	Number 1 Vol.3 (1), 2000
Number 1 Vol.2 (1), 1999	Number 1 Vol.1 (1), 1998

About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact