Balkan Journal of Medical Genetics

A NEW CLOCK IS RUNNING FOR MULTIPLE MYELOMA: CIRCADIAN CLOCK PROTEIN-PERIOD 3 (PER-3) POLYMORPHISM
Serin I.1,*, Pehlivan S.2, Demir I.3, Oyacı Y.2, Pehlivan M.3
*Corresponding Author: Istemi Serin, M.D., University of Health Sciences, Istanbul Training and Research Hospital, Department of Hematology, Org. Nafiz GURMAN Cad., Fatih, 34098 tel.: +90 532 3172393, e-mail: serinistemi@hotmail.com
page: 37

RESULTS

The median age was 56 years (range: 32-70). The 10-years OS was 79%, while the 10-years PFS was 47% with a median of 52.7 months. The mortality rate was 15.3% (n:23) (Table 1.). According to PER-3 gene variants, 4R/4R, 4R/5R and 5R/5R polymorphisms and 4R and 5R alleles did not differ between the MM and control groups (Table 2.). Table 3 shows the results of evaluating prognostic factors in terms of PFS and OS. In the 10-year survival analysis, the rate was shown as a percentage if it was above 50%, and as a month if it was below 50%. Median PFS in the 5R/5R genotype was found to be significantly longer, albeit low, at 86% (p = 0.046). In the statistical analysis performed between the 4R/4R genotype and other genotypes, the PFS of patients with this genotype was found to be significantly shorter with 40.4 months (p = 0.026). Table 4 shows the multivariate analysis. It was observed that patients with the 4R/4R genotype would have a risk of 2.049 times of shorter PFS (p= 0.009) (Figure 1.).

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