EVALUATION OF THE JAK2V617F MUTATIONAL BURDEN
IN PATIENTS WITH PHILADELPHIA CHROMOSOME
NEGATIVE MYELOPROLIFERATIVE NEOPLASMS:
A SINGLE-CENTER EXPERIENCE
Popova-Labachevska M1, Panovska-Stavridis I1,*, Eftimov A2, Kapedanovska Nestorovska A2,
Cevreska L1, Ivanovski M1, Ridova N1, Trajkova S1, Dimovski AJ2,*
*Corresponding Author: Associate Professor Irina Panovska-Stavridis, M.D., Ph.D., University Clinic
of Hematology, UKIM-Faculty of Medicine, University Cyril and Methodious,” Majka Tereza 47, Skopje,
RN Macedonia. Tel/Fax: +38923111749. E-mail: ukhematologija@t.mk and/or Professor Aleksandar J.
Dimovski, M.D., Ph.D., Center for Biomolecular Pharmaceutical Analyses, UKIM-Faculty of Pharmacy,
University “Ss Cyril and Methodius,” Majka Tereza 47, Skopje, RN Macedonia. Tel/Fax: +38923119694.
E-mail: adimovski@ff.ukim.edu.mk
page: 31
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CONCLUSIONS
presentation of the specific MPN is influenced by the
JAK2V617F mutational load. Moreover, they are consistent
with the already published data that >50.0% mutational
load of the JAK2V617F mutation could have a predictive
value regarding the clinical course and evolution of the
specific MPN entity. They also suggest that the implementation
of the JAK2 allele burden in a routine diagnostic
work-up of MPN patients could be a useful tool for the
refinement of the optimal treatment option [11].
Declaration of Interest. The authors report no conflicts
of interest. The authors alone are responsible for the
content and writing of this article.
Funding. This study was funded (in part) by research
funds of the Center for Biomolecular Pharmaceutical
Analyses, UMIM-Faculty of Pharmachy, Skopje, RN
Macedonia (to AJD).
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