EVALUATION OF THE JAK2V617F MUTATIONAL BURDEN IN PATIENTS WITH PHILADELPHIA CHROMOSOME NEGATIVE MYELOPROLIFERATIVE NEOPLASMS: A SINGLE-CENTER EXPERIENCE
Popova-Labachevska M1, Panovska-Stavridis I1,*, Eftimov A2, Kapedanovska Nestorovska A2, Cevreska L1, Ivanovski M1, Ridova N1, Trajkova S1, Dimovski AJ2,*
*Corresponding Author: Associate Professor Irina Panovska-Stavridis, M.D., Ph.D., University Clinic of Hematology, UKIM-Faculty of Medicine, University Cyril and Methodious,” Majka Tereza 47, Skopje, RN Macedonia. Tel/Fax: +38923111749. E-mail: ukhematologija@t.mk and/or Professor Aleksandar J. Dimovski, M.D., Ph.D., Center for Biomolecular Pharmaceutical Analyses, UKIM-Faculty of Pharmacy, University “Ss Cyril and Methodius,” Majka Tereza 47, Skopje, RN Macedonia. Tel/Fax: +38923119694. E-mail: adimovski@ff.ukim.edu.mk
page: 31

CONCLUSIONS

presentation of the specific MPN is influenced by the JAK2V617F mutational load. Moreover, they are consistent with the already published data that >50.0% mutational load of the JAK2V617F mutation could have a predictive value regarding the clinical course and evolution of the specific MPN entity. They also suggest that the implementation of the JAK2 allele burden in a routine diagnostic work-up of MPN patients could be a useful tool for the refinement of the optimal treatment option [11]. Declaration of Interest. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article. Funding. This study was funded (in part) by research funds of the Center for Biomolecular Pharmaceutical Analyses, UMIM-Faculty of Pharmachy, Skopje, RN Macedonia (to AJD).



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