IMPACT OF GENETICS ON NEOADJUVANT THERAPY
WITH COMPLETE PATHOLOGICAL RESPONSE
IN METASTATIC COLORECTAL CANCER:
CASE REPORT AND REVIEW OF THE LITERATURE
Bulajic P1, Bidzic N1,*, Djordjevic V1, Ceranic M1,2, Basaric D1,2, Pesic V3, Djordjevic-Pesic J4
*Corresponding Author: Nemanja Bidzic, M.D., Clinic for Digestive Surgery, Clinical Center of
Serbia, Koste Todorovica 6, Belgrade 11000, Serbia. Tel. +381-11-306-5957. Fax: +381-11-306-5967.
E-mail: nemanja bidzic@yahoo.com
page: 75
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CONCLUSIONS
There are literature data on similar efficiency of combined
cytotoxic and biological therapy, especially in the
neoadjuvant setting, as well as on its impact on long-term
survival. Genetic mutations as biomarkers have a crucial
role in the management of colorectal cancer stage IV, with
KRAS mutation status being significant in the choice of
neoadjuvant molecular targeted therapy. Our study has
shown that Bevacizumab-containing neoadjuvant treatment
can have rather promising results for both metastatic
and primary colorectal cancer. Pathological complete response is associated with
better overall survival and should be evaluated in future
research. We conclude that modern cancer therapy must be
individualized, multimodal and based on a genetic cancer
profile.
Declaration of Interest. The authors report no conflicts
of interest. The authors alone are responsible for the
content and writing of this article.
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