ASSOCIATION OF E-SELECTIN S128R POLYMORPHISM WITH HEREDITARY BREAST CARCINOMA SUSCEPTIBILITY IN TURKISH PATIENTS WITHOUT BRCA1/2 GERMLINE MUTATIONS
Yararbas K, Atalay PB
*Corresponding Author: Kanay Yararbas, M.D., Assistant Professor, Department of Medical Genetics, Acibadem Mehmet Ali Aydinlar University Faculty of Medicine; İçerenköy Mahallesi, Kayisdagi Caddesi, No: 32, 34742, Istanbul, Turkey. Tel: +90-216-500-4785. Fax: +90-216-500-5076. E-mail: kanay.yararbas@ acibadem.edu.tr
page: 27

DISCUSSION

E-selectin is involved in cancer metastasis by regulating the adhesion of circulating cancer cells to the endothelial cells of blood vessels [10]. Currently, several SNPs of the E-selectin gene have been identified. The S128R polymorphism (A>C variation), the most common SNP of the E-selectin gene, facilitates ligand binding, which in turn increases the adhesion of lymphoid and myeloid cells to the endothelium. The E-selectin S128R polymorphism is associated with an increased risk of several cancers including gastric [25,26], colorectal [27] and pancreatic [28] cancers. However, a very limited number of studies investigating the association of the E-selectin S128R polymorphism with breast cancer susceptibility have revealed contradictory results. Kontogianni et al. [29] reported that the E-selectin S128R genotypes (AA, AC, and CC) were not associated with any of the tumor parameters in a Caucasian population. On the other hand, Naidu et al. [30] reported that women carrying the E-selectin S128R polymorphism showed a significantly increased breast cancer risk in an Asian population. Different results from these studies may imply that the effects of the S128R polymorphism on breast cancer susceptibility may be population-dependent. In the present study, we examined whether the S128R polymorphism is associated with susceptibility to breast carcinoma in BRCA1/2 mutation non carriers with breast cancer in the Turkish population. This study is the first to investigate the association between the E-selectin S128R polymorphism and breast cancer in the Turkish population as well as to investigate the association of the E-selectin S128R polymorphism with development of breast cancer in the absence of BRCA1/2 mutations. For this purpose, 90 BRCA1/2 mutation non carriers with breast cancer and 270 controls with no previous cancer history, were genotyped using RT-PCR. The results of the present study demonstrated that the E-selectin S128R polymorphism was not associated with an increased risk of breast cancer in BRCA1/2 mutation non carriers with breast cancer in the Turkish population. Further studies with larger sample sizes are required to reveal the association between the E-selectin S128R polymorphism and breast cancer risk in the absence and presence of BRCA1/2 mutations.



Number 21
VOL. 21 (1), 2018
Number 21
VOL. 21, 2018 Accepted articles (Accepted, unedited articles, published online and can be cited. The final edited and printed version of the manuscript will appear in future)
Number 21
VOL. 21, 2018 Supplement
Number 20
VOL. 20 (2), 2017
Number 20
VOL. 20 (1), 2017
Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006